The Carcinogenic Properties of Overlooked yet Prevalent Polycyclic Aromatic Hydrocarbons in Human Lung Epithelial Cells.

1-methylanthracene benzo[a]pyrene co-carcinogenic epithelial cells fluoranthene gap junctions lung micronuclei polycyclic aromatic hydrocarbons

Journal

Toxics
ISSN: 2305-6304
Titre abrégé: Toxics
Pays: Switzerland
ID NLM: 101639637

Informations de publication

Date de publication:
09 Jan 2022
Historique:
received: 28 11 2021
revised: 19 12 2021
accepted: 06 01 2022
entrez: 20 1 2022
pubmed: 21 1 2022
medline: 21 1 2022
Statut: epublish

Résumé

The WHO classified air pollution as a human lung carcinogen and polycyclic aromatic hydrocarbons (PAHs) are components of both indoor (e.g., tobacco smoke and cookstoves) and outdoor (e.g., wildfires and industrial and vehicle emissions) air pollution, thus a human health concern. However, few studies have evaluated the adverse effects of low molecular weight (LMW) PAHs, the most abundant PAHs in the environment. We hypothesized that LMW PAHs combined with the carcinogenic PAH benzo[

Identifiants

pubmed: 35051070
pii: toxics10010028
doi: 10.3390/toxics10010028
pmc: PMC8779510
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : NIEHS NIH HHS
ID : R15ES024893
Pays : United States
Organisme : Deutsche Gesetzliche Unfallversicherung
ID : Intramural research program

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Auteurs

Alison K Bauer (AK)

Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Katelyn J Siegrist (KJ)

Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Melanie Wolff (M)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), 44789 Bochum, Germany.

Lindsey Nield (L)

Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Thomas Brüning (T)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), 44789 Bochum, Germany.

Brad L Upham (BL)

Department of Pediatrics and Human Development, Michigan State University, East Lansing, MI 48824, USA.

Heiko U Käfferlein (HU)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), 44789 Bochum, Germany.

Sabine Plöttner (S)

Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr-University Bochum (IPA), 44789 Bochum, Germany.

Classifications MeSH