Exploring New Kingdoms: The Role of Extracellular Vesicles in Oxi-Inflamm-Aging Related to Cardiorenal Syndrome.

age-related pathologies aging extracellular vesicles inflammation oxi-inflamm-aging oxidative stress senescence senolytics

Journal

Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981

Informations de publication

Date de publication:
29 Dec 2021
Historique:
received: 18 10 2021
revised: 20 12 2021
accepted: 23 12 2021
entrez: 21 1 2022
pubmed: 22 1 2022
medline: 22 1 2022
Statut: epublish

Résumé

The incidence of age associated chronic diseases has increased in recent years. Although several diverse causes produce these phenomena, abundant evidence shows that oxidative stress plays a central role. In recent years, numerous studies have focused on elucidating the role of oxidative stress in the development and progression of both aging and chronic diseases, opening the door to the discovery of new underlying mechanisms and signaling pathways. Among them, senolytics and senomorphics, and extracellular vesicles offer new therapeutic strategies to slow the development of aging and its associated chronic diseases by decreasing oxidative stress. In this review, we aim to discuss the role of extracellular vesicles in human cardiorenal syndrome development and their possible role as biomarkers, targets, or vehicles of drugs to treat this syndrome.

Identifiants

pubmed: 35052582
pii: antiox11010078
doi: 10.3390/antiox11010078
pmc: PMC8773353
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Instituto de Salud Carlos III
ID : PI19/00240
Organisme : Ministry of Economy, Industry and Competitiveness
ID : SAF 2015-69295-R
Organisme : Ministerio de Cultura y Deporte. Spain
ID : RAEFEC-URJC 30/UPB/21
Organisme : Comunidad de Madrid
ID : B2017/BMD-3676
Organisme : King Juan Carlos University
ID : INFLAMAPROSTHIP
Organisme : Ministry of Economy, Industry and Competitiveness
ID : SAF-2016-80305-P
Organisme : Ministry of Economy, Industry and Competitiveness
ID : IJCI-2017-31399
Organisme : Ministry of Science and Innovation, Spain
ID : PID2020-113839RB-I00
Organisme : Ministry of Economy, Industry and Competitiveness
ID : PCIN-2017-117
Organisme : EU Joint Programming Initiative
ID : JPI HDHL INTIMIC-085
Organisme : Centro de Investigación en Red en Enfermedades Cardiovasculares
ID : CB16/11/00286

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Auteurs

Cristina Mas-Bargues (C)

Grupo de Investigación Freshage, Departmento de Fisiología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain.
Instituto Sanitario de Investigación INCLIVA, 46010 Valencia, Spain.
Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III (CIBERFES, ISCIII), 28029 Madrid, Spain.

Matilde Alique (M)

Departamento de Biología de Sistemas, Universidad de Alcalá, 28871 Madrid, Spain.
Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, Spain.

María Teresa Barrús-Ortiz (MT)

Área de Fisiología, Departamento de Ciencias Básicas de la Salud, Facultad de Ciencias de la Salud, Univesidad Rey Juan Carlos, Avenida de Atenas s/n, 28922 Madrid, Spain.

Consuelo Borrás (C)

Grupo de Investigación Freshage, Departmento de Fisiología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain.
Instituto Sanitario de Investigación INCLIVA, 46010 Valencia, Spain.
Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III (CIBERFES, ISCIII), 28029 Madrid, Spain.

Raquel Rodrigues-Díez (R)

Departamento de Farmacología, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain.
Instituto de Investigación Hospital La Paz (IdiPAZ), 28046 Madrid, Spain.
Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares (CIBERCV), 08036 Barcelona, Spain.

Classifications MeSH