Anorectal and Genital Mucosal Melanoma: Diagnostic Challenges, Current Knowledge and Therapeutic Opportunities of Rare Melanomas.
BRAF mutation
KIT mutation
anorectal melanoma
immune checkpoints inhibitor
mucosal melanoma
multidisciplinary approach
penile melanoma
rare melanoma
rare tumors
referral center
targeted therapy
vaginal melanoma
vulvar melanoma
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
11 Jan 2022
11 Jan 2022
Historique:
received:
13
12
2021
revised:
07
01
2022
accepted:
08
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Mucosal melanomas (MM) are rare tumors, being less than 2% of all diagnosed melanomas, comprising a variegated group of malignancies arising from melanocytes in virtually all mucosal epithelia, even if more frequently found in oral and sino-nasal cavities, ano-rectum and female genitalia (vulva and vagina). To date, there is no consensus about the optimal management strategy of MM. Furthermore, the clinical rationale of molecular tumor characterization regarding BRAF, KIT or NRAS, as well as the therapeutic value of immunotherapy, chemotherapy and targeted therapy, has not yet been deeply explored and clearly established in MM. In this overview, focused on anorectal and genital MM as models of rare melanomas deserving of a multidisciplinary approach, we highlight the need of referring these patients to centers with experts in melanoma, anorectal and uro-genital cancers treatments. Taking into account the rarity, the poor outcomes and the lack of effective treatment options for MM, tailored research needs to be promptly promoted.
Identifiants
pubmed: 35052829
pii: biomedicines10010150
doi: 10.3390/biomedicines10010150
pmc: PMC8773579
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Références
Cancer. 2016 Nov 15;122(21):3354-3362
pubmed: 27533633
Obstet Gynecol. 2007 Aug;110(2 Pt 1):296-301
pubmed: 17666603
Cancer. 2005 Mar 1;103(5):1000-7
pubmed: 15651058
Clin Cancer Res. 2008 Nov 1;14(21):6821-8
pubmed: 18980976
Gynecol Oncol. 2013 Jun;129(3):533-7
pubmed: 23480869
PLoS One. 2014 Nov 10;9(11):e112535
pubmed: 25383553
Obstet Gynecol. 1975 Jun;45(6):638-46
pubmed: 1143724
Eur J Cancer. 2020 Sep;137:127-135
pubmed: 32763783
Clin Cancer Res. 2012 Mar 1;18(5):1457-63
pubmed: 22261812
Clin Cancer Res. 2011 Jun 15;17(12):3933-42
pubmed: 21680547
Head Neck. 2016 Sep;38(9):1310-7
pubmed: 27043023
Int J Gynecol Cancer. 2016 Sep;26(7):1307-12
pubmed: 27465889
J Gynecol Oncol. 2019 Nov;30(6):e94
pubmed: 31576688
Cancer. 1994 May 15;73(10):2626-32
pubmed: 8174062
Cancers (Basel). 2020 Aug 21;12(9):
pubmed: 32825562
Nat Commun. 2014;5:3116
pubmed: 24445538
Radiology. 2004 Jul;232(1):181-6
pubmed: 15220501
Curr Oncol Rep. 2012 Oct;14(5):441-8
pubmed: 22661391
J Am Coll Surg. 2013 Aug;217(2):324-35
pubmed: 23697834
J Am Acad Dermatol. 2014 Aug;71(2):366-75
pubmed: 24815565
Updates Surg. 2015 Dec;67(4):367-71
pubmed: 26070991
Cancer Discov. 2017 Aug;7(8):818-831
pubmed: 28572459
J Clin Aesthet Dermatol. 2013 Sep;6(9):18-26
pubmed: 24062870
Melanoma Manag. 2018 Oct 08;5(3):MMT11
pubmed: 30459941
Cancer Lett. 2001 Aug 28;169(2):107-14
pubmed: 11431098
J Cancer Res Clin Oncol. 2010 Sep;136(9):1401-5
pubmed: 20130908
Mod Pathol. 2017 Feb;30(2):286-296
pubmed: 27739435
Clin Cancer Res. 2015 May 15;21(10):2289-96
pubmed: 25695690
Int Braz J Urol. 2013 Nov-Dec;39(6):823-31
pubmed: 24456774
Oncol Res. 2019 Mar 29;27(4):495-501
pubmed: 30075827
Virchows Arch. 2019 Apr;474(4):421-432
pubmed: 30747264
Nat Commun. 2019 Jul 18;10(1):3163
pubmed: 31320640
J Obstet Gynaecol. 2014 Feb;34(2):165-8
pubmed: 24456439
Lancet Oncol. 2020 Feb;21(2):271-282
pubmed: 31838007
Front Oncol. 2019 Sep 04;9:835
pubmed: 31552171
Am Surg. 2006 Oct;72(10):917-20
pubmed: 17058735
Cancer. 1993 Mar 1;71(5):1893-7
pubmed: 8448754
Ann Oncol. 2009 Aug;20 Suppl 6:vi22-9
pubmed: 19617294
Melanoma Res. 2009 Feb;19(1):58-60
pubmed: 19430407
Br J Cancer. 2008 Dec 16;99(12):2065-9
pubmed: 19018266
Future Oncol. 2016 Nov;12(22):2531-2534
pubmed: 27715206
Cancer. 1987 Feb 1;59(3):581-7
pubmed: 3791167
Obstet Gynecol. 1989 Aug;74(2):190-9
pubmed: 2748055
Br J Surg. 2010 Jan;97(1):98-103
pubmed: 20013935
Ann Oncol. 2017 Jun 1;28(6):1380-1387
pubmed: 28327988
Int J Gynecol Cancer. 2013 Jul;23(6):1118-25
pubmed: 23765206
Cancers (Basel). 2020 Feb 26;12(3):
pubmed: 32110946
Br J Surg. 2004 Sep;91(9):1183-7
pubmed: 15449271
Head Neck. 2003 Jun;25(6):423-8
pubmed: 12784232
Tunis Med. 2010 Jun;88(6):430-2
pubmed: 20517856
Eur J Obstet Gynecol Reprod Biol. 2005 Aug 1;121(2):243-8
pubmed: 16054970
Lancet Oncol. 2008 Oct;9(10):973-81
pubmed: 19071254
Am J Surg Pathol. 2002 Nov;26(11):1450-7
pubmed: 12409721
Ann R Coll Surg Engl. 2010 Jan;92(1):W10-2
pubmed: 20056049
Front Oncol. 2021 Jul 19;11:702287
pubmed: 34350118
Eur J Cancer. 2021 Mar;145:210-220
pubmed: 33503528
Ther Adv Med Oncol. 2020 May 18;12:1758835920922028
pubmed: 32489431
Ann Surg Oncol. 2004 Jan;11(1):34-9
pubmed: 14699031
J Eur Acad Dermatol Venereol. 2018 Jan;32(1):e39-e40
pubmed: 28750150
Oncotarget. 2018 Jan 2;9(9):8785-8800
pubmed: 29492238
Biomedicines. 2021 Nov 24;9(12):
pubmed: 34944576
Clin Colon Rectal Surg. 2009 May;22(2):120-6
pubmed: 20436837
Surgery. 1998 Jul;124(1):38-48
pubmed: 9663250
Dis Colon Rectum. 1997 Jun;40(6):661-8
pubmed: 9194459
Gynecol Oncol. 1990 May;37(2):264-7
pubmed: 2344972
Br J Cancer. 2003 Dec 1;89(11):2019-22
pubmed: 14647131
J Transl Med. 2019 Jul 29;17(1):245
pubmed: 31358010
Gynecol Oncol. 2011 Sep;122(3):612-7
pubmed: 21570710
Gynecol Oncol. 2003 Jan;88(1):45-50
pubmed: 12504626
Front Oncol. 2020 Sep 02;10:1707
pubmed: 32984050
J Natl Cancer Inst. 2014 Sep 13;106(9):
pubmed: 25217772
Acta Oncol. 2009;48(1):125-31
pubmed: 18607861
J Clin Oncol. 2017 Jan 10;35(2):226-235
pubmed: 28056206
Cancer. 1964 Jul;17:912-3
pubmed: 14179553
Ann Surg Treat Res. 2014 Sep;87(3):113-7
pubmed: 25247163
Science. 2018 Nov 30;362(6418):1055-1060
pubmed: 30385465
Br J Cancer. 2018 Sep;119(6):670-674
pubmed: 30202085
Gynecol Oncol Rep. 2016 Apr 14;16:42-6
pubmed: 27331137
Clin Cancer Res. 2013 Aug 15;19(16):4488-98
pubmed: 23833309
Gynecol Oncol. 1983 Oct;16(2):153-68
pubmed: 6629120
Surg Clin North Am. 2003 Apr;83(2):323-42
pubmed: 12744612
Int J Womens Health. 2015 Mar 20;7:305-13
pubmed: 25848321
Urologia. 2021 Sep 16;:3915603211046471
pubmed: 34528492
Cancer. 2004 Apr 1;100(7):1478-83
pubmed: 15042682
Dis Colon Rectum. 2010 Apr;53(4):402-8
pubmed: 20305438
Gynecol Oncol. 1998 Dec;71(3):476-80
pubmed: 9887254
Cancer Imaging. 2014 Nov 12;14:30
pubmed: 25609545
Mol Cancer Ther. 2018 Jan;17(1):222-231
pubmed: 29054983
Ann Surg Oncol. 2010 Jan;17(1):40-4
pubmed: 19774417
J Med Genet. 2004 Apr;41(4):270-2
pubmed: 15060100
Melanoma Res. 2004 Dec;14(6):517-20
pubmed: 15577323
J Natl Cancer Inst. 2019 Oct 1;111(10):1068-1077
pubmed: 30657954
Radiol Oncol. 2010 Mar;44(1):1-12
pubmed: 22933884
J Low Genit Tract Dis. 2015 Oct;19(4):350-3
pubmed: 26225944
Cancer. 2002 Jan 15;94(2):486-91
pubmed: 11905414
Cancer. 1953 Jan;6(1):1-45
pubmed: 13009650
Am J Obstet Gynecol. 1979 Apr 1;133(7):825-32
pubmed: 434024
Am J Surg Pathol. 2000 Jun;24(6):785-96
pubmed: 10843280
Oral Oncol. 2015 Aug;51(8):e65-6
pubmed: 26070422
J Urol. 1988 Jul;140(1):72-5
pubmed: 3379702
Gynecol Oncol. 2008 Mar;108(3):577-83
pubmed: 18155274
Nat Commun. 2014 Sep 10;5:4846
pubmed: 25204415
Pigment Cell Melanoma Res. 2013 Jul;26(4):518-26
pubmed: 23582185
Int J Mol Med. 2014 Apr;33(4):784-94
pubmed: 24535703
World J Surg Oncol. 2009 Aug 11;7:64
pubmed: 19671138
Cancer. 2011 Oct 15;117(20):4747-55
pubmed: 21446049
Langenbecks Arch Surg. 2010 Aug;395(6):757-60
pubmed: 20066546
Crit Rev Oncol Hematol. 2012 Feb;81(2):185-95
pubmed: 21515070
Coll Antropol. 2007 Jan;31 Suppl 1:13-6
pubmed: 17469742
Mod Pathol. 2014 Oct;27(10):1386-93
pubmed: 24603591
Cancers (Basel). 2019 Aug 08;11(8):
pubmed: 31398831
Gynecol Oncol. 1992 Jun;45(3):254-8
pubmed: 1612500
BMC Urol. 2015 Jul 14;15:68
pubmed: 26169921
J Oncol. 2018 Dec 2;2018:1908065
pubmed: 30631354
Eur J Cancer. 2020 Aug;135:22-30
pubmed: 32531566
Crit Rev Oncol Hematol. 2017 Apr;112:136-152
pubmed: 28325255
J Urol. 1974 Feb;111(2):198-200
pubmed: 4810764
Clin Cancer Res. 2017 Nov 15;23(22):6946-6957
pubmed: 28830923
Dis Colon Rectum. 1995 Feb;38(2):146-51
pubmed: 7851168
Int J Gynecol Cancer. 2004 Sep-Oct;14(5):875-81
pubmed: 15361198
Semin Cancer Biol. 2020 Apr;61:139-148
pubmed: 31655118
Dis Colon Rectum. 1990 Oct;33(10):874-7
pubmed: 1698595
Ecancermedicalscience. 2017 Apr 04;11:731
pubmed: 28487750
Nature. 2013 Oct 17;502(7471):333-339
pubmed: 24132290
Int J Mol Sci. 2021 Mar 27;22(7):
pubmed: 33801689
J Clin Oncol. 2018 Mar 1;36(7):667-673
pubmed: 28991513
Cancer. 2011 May 15;117(10):2202-8
pubmed: 21523734
Melanoma Res. 2010 Apr;20(2):153-8
pubmed: 20147857
Urol Case Rep. 2018 Mar 13;18:54-56
pubmed: 29785370
Melanoma Res. 2017 Jun;27(3):189-199
pubmed: 28296713
Oncogene. 2020 Sep;39(36):5811-5824
pubmed: 32733068
Gynecol Oncol. 2001 Dec;83(3):457-65
pubmed: 11733955
Cancer Treat Res. 2016;167:295-320
pubmed: 26601869
J Low Genit Tract Dis. 2016 Jul;20(3):e24-9
pubmed: 27030881
Lancet Oncol. 2013 Mar;14(3):249-56
pubmed: 23414587
Clin Colon Rectal Surg. 2006 May;19(2):78-87
pubmed: 20011314
Biochem Pharmacol. 2010 Sep 1;80(5):568-74
pubmed: 20457136
Melanoma Res. 2008 Apr;18(2):127-33
pubmed: 18337649
Urology. 2007 Jul;70(1):143-7
pubmed: 17656225
Urology. 2014 Jan;83(1):6-11
pubmed: 23978371
Sao Paulo Med J. 2010 Jan;128(1):38-41
pubmed: 20512279
Int J Gynecol Cancer. 2014 Nov;24(9 Suppl 3):S117-22
pubmed: 24987924
Cancer Imaging. 2013 Dec 30;13(4):626-32
pubmed: 24434078
J Clin Oncol. 2013 May 10;31(14):1767-74
pubmed: 23569304
JAMA. 2011 Jun 8;305(22):2327-34
pubmed: 21642685
Nat Rev Mol Cell Biol. 2006 Sep;7(9):667-77
pubmed: 16921403
Am J Surg. 2005 Apr;189(4):446-9
pubmed: 15820458
Lancet Oncol. 2020 Apr;21(4):531-540
pubmed: 32105622
Am J Surg Pathol. 2018 Aug;42(8):1052-1058
pubmed: 29683819
J Clin Oncol. 2013 Sep 10;31(26):3182-90
pubmed: 23775962
Bull Cancer. 2014 Jan 1;101(1):102-6
pubmed: 24445910
Mol Cancer Ther. 2020 Nov;19(11):2308-2318
pubmed: 32943547
Eur J Nucl Med Mol Imaging. 2020 Sep;47(10):2301-2312
pubmed: 32206839
Oncotarget. 2017 Jun 20;8(25):40683-40692
pubmed: 28380455
J Am Acad Dermatol. 2012 Oct;67(4):598-605
pubmed: 22243767
Ann Surg. 2006 Dec;244(6):1012-7
pubmed: 17122627
Mol Clin Oncol. 2017 Mar;6(3):373-376
pubmed: 28451415
J Urol. 2005 Jun;173(6):1958-65
pubmed: 15879790
J Am Coll Surg. 2003 Feb;196(2):206-11
pubmed: 12595048
Am J Obstet Gynecol. 1994 Nov;171(5):1225-30
pubmed: 7977524
Invest New Drugs. 2012 Oct;30(5):2008-14
pubmed: 22068222