Humoral Immune Response in IBD Patients Three and Six Months after Vaccination with the SARS-CoV-2 mRNA Vaccines mRNA-1273 and BNT162b2.
COVID-19
IBD patients
SARS-CoV-2
seroconversion
vaccination
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
13 Jan 2022
13 Jan 2022
Historique:
received:
21
12
2021
revised:
09
01
2022
accepted:
11
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronovirus-2 (SARS-CoV-2) is the cause of the coronavirus disease 2019 (COVID-19) pandemic. Vaccination is considered the core approach to containing the pandemic. There is currently insufficient evidence on the efficacy of these vaccines in immunosuppressed inflammatory bowel disease (IBD) patients. The aim of this study was to investigate the humoral response in immunosuppressed IBD patients after COVID-19 mRNA vaccination. In this prospective study, IgG antibody levels (AB) against the SARS-CoV-2 receptor-binding domain (spike-protein) were quantitatively determined. For assessing the potential neutralizing capacity, a SARS-CoV-2 surrogate neutralization test (sVNT) was employed in IBD patients (
Identifiants
pubmed: 35052849
pii: biomedicines10010171
doi: 10.3390/biomedicines10010171
pmc: PMC8774019
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Innovative Medizinische Forschung (IMF), Medizinische Fakultät, Westfälische Wil-helms-Universität Münster, Germany
ID : TE212102
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