Effects of Resistance Training on Oxidative Stress Markers and Muscle Damage in Spinal Cord Injured Rats.
muscle damage
oxidative stress
resistance training
spinal cord injury
Journal
Biology
ISSN: 2079-7737
Titre abrégé: Biology (Basel)
Pays: Switzerland
ID NLM: 101587988
Informations de publication
Date de publication:
27 Dec 2021
27 Dec 2021
Historique:
received:
22
10
2021
revised:
15
12
2021
accepted:
18
12
2021
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Spinal cord injury (SCI) is a condition that affects the central nervous system, is characterized by motor and sensory impairments, and impacts individuals' lives. The objective of this study was to evaluate the effects of resistance training on oxidative stress and muscle damage in spinal cord injured rats. Forty Wistar rats were selected and divided equally into five groups: Healthy Control (CON), Sham (SHAM) SCI Untrained group (SCI-U), SCI Trained group (SCI- T), SCI Active Trained group (SCI- AT). Animals in the trained groups were submitted to an incomplete SCI at T9. Thereafter, they performed a protocol of resistance training for four weeks. Significant differences in muscle damage markers and oxidative stress in the trained groups, mainly in SCI- AT, were found. On the other hand, SCI- U group presented higher levels of oxidative stress and biomarkers of LDH and AST. The results highlight that resistance training promoted a decrease in oxidative stress and a significative response in muscle damage markers.
Sections du résumé
BACKGROUND
BACKGROUND
Spinal cord injury (SCI) is a condition that affects the central nervous system, is characterized by motor and sensory impairments, and impacts individuals' lives. The objective of this study was to evaluate the effects of resistance training on oxidative stress and muscle damage in spinal cord injured rats.
METHODOLOGY
METHODS
Forty Wistar rats were selected and divided equally into five groups: Healthy Control (CON), Sham (SHAM) SCI Untrained group (SCI-U), SCI Trained group (SCI- T), SCI Active Trained group (SCI- AT). Animals in the trained groups were submitted to an incomplete SCI at T9. Thereafter, they performed a protocol of resistance training for four weeks.
RESULTS
RESULTS
Significant differences in muscle damage markers and oxidative stress in the trained groups, mainly in SCI- AT, were found. On the other hand, SCI- U group presented higher levels of oxidative stress and biomarkers of LDH and AST.
CONCLUSION
CONCLUSIONS
The results highlight that resistance training promoted a decrease in oxidative stress and a significative response in muscle damage markers.
Identifiants
pubmed: 35053030
pii: biology11010032
doi: 10.3390/biology11010032
pmc: PMC8772953
pii:
doi:
Types de publication
Journal Article
Langues
eng
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