Calcium Signals during SARS-CoV-2 Infection: Assessing the Potential of Emerging Therapies.
Ca2+ channels
SARS-CoV-2
calcium
therapeutics
viral infections
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
12 01 2022
12 01 2022
Historique:
received:
11
12
2021
revised:
05
01
2022
accepted:
11
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
2
2
2022
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). This respiratory illness was declared a pandemic by the world health organization (WHO) in March 2020, just a few weeks after being described for the first time. Since then, global research effort has considerably increased humanity's knowledge about both viruses and disease. It has also spawned several vaccines that have proven to be key tools in attenuating the spread of the pandemic and severity of COVID-19. However, with vaccine-related skepticism being on the rise, as well as breakthrough infections in the vaccinated population and the threat of a complete immune escape variant, alternative strategies in the fight against SARS-CoV-2 are urgently required. Calcium signals have long been known to play an essential role in infection with diverse viruses and thus constitute a promising avenue for further research on therapeutic strategies. In this review, we introduce the pivotal role of calcium signaling in viral infection cascades. Based on this, we discuss prospective calcium-related treatment targets and strategies for the cure of COVID-19 that exploit viral dependence on calcium signals.
Identifiants
pubmed: 35053369
pii: cells11020253
doi: 10.3390/cells11020253
pmc: PMC8773957
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FWF Austrian Science Fund
ID : P32075-B
Organisme : FWF Austrian Science Fund
ID : P32947
Organisme : FWF Austrian Science Fund
ID : W1250 NanoCell
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