Scaffold-Mediated Immunoengineering as Innovative Strategy for Tendon Regeneration.
biomolecules
electrospinning
immune cells
immune response
immunoengineering
mechanotransduction
scaffold
stem cells
tendon regeneration
tissue engineering
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
13 01 2022
13 01 2022
Historique:
received:
06
12
2021
revised:
06
01
2022
accepted:
10
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
24
2
2022
Statut:
epublish
Résumé
Tendon injuries are at the frontier of innovative approaches to public health concerns and sectoral policy objectives. Indeed, these injuries remain difficult to manage due to tendon's poor healing ability ascribable to a hypo-cellularity and low vascularity, leading to the formation of a fibrotic tissue affecting its functionality. Tissue engineering represents a promising solution for the regeneration of damaged tendons with the aim to stimulate tissue regeneration or to produce functional implantable biomaterials. However, any technological advancement must take into consideration the role of the immune system in tissue regeneration and the potential of biomaterial scaffolds to control the immune signaling, creating a pro-regenerative environment. In this context, immunoengineering has emerged as a new discipline, developing innovative strategies for tendon injuries. It aims at designing scaffolds, in combination with engineered bioactive molecules and/or stem cells, able to modulate the interaction between the transplanted biomaterial-scaffold and the host tissue allowing a pro-regenerative immune response, therefore hindering fibrosis occurrence at the injury site and guiding tendon regeneration. Thus, this review is aimed at giving an overview on the role exerted from different tissue engineering actors in leading immunoregeneration by crosstalking with stem and immune cells to generate new paradigms in designing regenerative medicine approaches for tendon injuries.
Identifiants
pubmed: 35053383
pii: cells11020266
doi: 10.3390/cells11020266
pmc: PMC8773518
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Perspective for Future Innovation in Tendon Repair H2020-MSCA-ITN-EJD-P4 FIT
ID : 955685
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