Dynamic Cancer Cell Heterogeneity: Diagnostic and Therapeutic Implications.
heterogeneity
implication
molecular level
thyroid cancer
tumor ecosystem
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
07 Jan 2022
07 Jan 2022
Historique:
received:
06
12
2021
revised:
04
01
2022
accepted:
05
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Though heterogeneity of cancers is recognized and has been much discussed in recent years, the concept often remains overlooked in different routine examinations. Indeed, in clinical or biological articles, reviews, and textbooks, cancers and cancer cells are generally presented as evolving distinct entities rather than as an independent heterogeneous cooperative cell population with its self-oriented biology. There are, therefore, conceptual gaps which can mislead the interpretations/diagnostic and therapeutic approaches. In this short review, we wish to summarize and discuss various aspects of this dynamic evolving heterogeneity and its biological, pathological, clinical, diagnostic, and therapeutic implications, using thyroid carcinoma as an illustrative example.
Identifiants
pubmed: 35053446
pii: cancers14020280
doi: 10.3390/cancers14020280
pmc: PMC8773841
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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