Naloxegol and Postoperative Urinary Retention: A Randomized Trial.
anesthesia
naloxegol
residual bladder urine volume
urinary retention
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
17 Jan 2022
17 Jan 2022
Historique:
received:
10
11
2021
revised:
10
01
2022
accepted:
13
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown. patients given naloxegol have lower residual bladder urine volume than those given placebo. 136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes. 67 were randomized to naloxegol and 64 to placebo. We did not identify a significant effect on urine residual volume, with an estimated ratio of geometric means of 0.9 (0.3, 2.6), Our results do not support use of naloxegol for postoperative urinary retention after hip and knee surgery.
Sections du résumé
BACKGROUND
BACKGROUND
Naloxegol antagonizes peripheral opioid-related side effects without preventing opioid-related analgesia. However, the effect of naloxegol on opioid-induced bladder dysfunction remains unknown.
HYPOTHESIS
OBJECTIVE
patients given naloxegol have lower residual bladder urine volume than those given placebo.
METHODS
METHODS
136 patients scheduled for elective hip and knee surgery were randomized to oral naloxegol or placebo given the morning of surgery, and on the first two postoperative mornings. Residual urine volume was measured ultrasonographically within 30 min after voiding once in the morning and once in the afternoon for two postoperative days. Opioid-related Symptom Distress Scale (ORSDS), the need for indwelling urinary catheterization, and quality of recovery (QoR) score were secondary outcomes.
RESULTS
RESULTS
67 were randomized to naloxegol and 64 to placebo. We did not identify a significant effect on urine residual volume, with an estimated ratio of geometric means of 0.9 (0.3, 2.6),
CONCLUSIONS
CONCLUSIONS
Our results do not support use of naloxegol for postoperative urinary retention after hip and knee surgery.
Identifiants
pubmed: 35054148
pii: jcm11020454
doi: 10.3390/jcm11020454
pmc: PMC8780376
pii:
doi:
Types de publication
Journal Article
Langues
eng
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