Pulmonary Arteriovenous Pressure Gradient and Time-Averaged Mean Velocity of Small Pulmonary Arteries Can Serve as Sensitive Biomarkers in the Diagnosis of Pulmonary Arterial Hypertension: A Preclinical Study by 4D-Flow MRI.

4D-flow cardiac magnetic resonance hemodynamics pulmonary hypertension treatment response

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
28 Dec 2021
Historique:
received: 15 11 2021
revised: 18 12 2021
accepted: 21 12 2021
entrez: 21 1 2022
pubmed: 22 1 2022
medline: 22 1 2022
Statut: epublish

Résumé

(1) Background: Pulmonary arterial hypertension (PAH) is a serious condition that is associated with many cardiopulmonary diseases. Invasive right heart catheterization (RHC) is currently the only method for the definitive diagnosis and follow-up of PAH. In this study, we sought a non-invasive hemodynamic biomarker for the diagnosis of PAH. (2) Methods: We applied prospectively respiratory and cardiac gated 4D-flow MRI at a 9.4T preclinical scanner on three different groups of Sprague Dawley rats: baseline (

Identifiants

pubmed: 35054225
pii: diagnostics12010058
doi: 10.3390/diagnostics12010058
pmc: PMC8774481
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Federal Ministry of Education and Research
ID : FKZ 01EO1502
Organisme : Open Access Publication Fund of the University of Bonn
ID : no grant number available

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Auteurs

Ali Nahardani (A)

Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany.
Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, 53127 Bonn, Germany.

Simon Leistikow (S)

Department of Mathematics and Computer Science, Institute of Computer Science, Westfälische Wilhelms-Universität Münster, 48149 Munster, Germany.

Katja Grün (K)

Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, 07747 Jena, Germany.

Martin Krämer (M)

Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany.

Karl-Heinz Herrmann (KH)

Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany.

Andrea Schrepper (A)

Department of Cardiothoracic Surgery, Jena University Hospital, 07747 Jena, Germany.

Christian Jung (C)

Department of Internal Medicine, Division of Cardiology, University Hospital Düsseldorf, 40225 Dusseldorf, Germany.

Sara Moradi (S)

Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, 53127 Bonn, Germany.

Paul Christian Schulze (PC)

Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, 07747 Jena, Germany.

Lars Linsen (L)

Department of Mathematics and Computer Science, Institute of Computer Science, Westfälische Wilhelms-Universität Münster, 48149 Munster, Germany.

Jürgen R Reichenbach (JR)

Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany.

Verena Hoerr (V)

Medical Physics Group, Institute of Diagnostic and Interventional Radiology, Jena University Hospital, Friedrich Schiller University Jena, 07747 Jena, Germany.
Heart Center Bonn, Department of Internal Medicine II, University Hospital Bonn, 53127 Bonn, Germany.
Translational Research Imaging Center (TRIC), Clinic for Radiology, University Hospital Münster, 48149 Munster, Germany.

Marcus Franz (M)

Department of Internal Medicine I, Division of Cardiology, Angiology, Pneumology, and Intensive Medical Care, Jena University Hospital, 07747 Jena, Germany.

Classifications MeSH