The Prevalence of MRI-Defined Sacroiliitis and Classification of Spondyloarthritis in Patients with Acute Anterior Uveitis: A Longitudinal Single-Centre Cohort Study.
axial spondyloarthritis
magnetic resonance imaging
peripheral spondyloarthritis
sacroiliitis
spondyloarthritis
uveitis
Journal
Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402
Informations de publication
Date de publication:
11 Jan 2022
11 Jan 2022
Historique:
received:
29
11
2021
revised:
03
01
2022
accepted:
07
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Acute anterior uveitis (AAU) is a relatively common extra-musculoskeletal manifestation of axial spondyloarthritis (axSpA); however, data on the prevalence of active sacroiliitis in patients with AAU are limited. 102 patients with AAU and 39 healthy subjects (HS) underwent clinical assessment and sacroiliac joint MRI. Patients with absence of active sacroiliitis were reassessed after two years. International Spondyloarthritis Society (ASAS) classification criteria for axSpA (regardless of patient's age) and expert opinion for definitive diagnosis of axSpA were applied. Although chronic back pain was equally present in both groups, bone marrow edema (BME) in SIJ and BME highly suggestive of axSpA was found in 52 (51%) and in 33 (32%) patients with AAU compared with 11 (28%) and none in HS, respectively. Out of all AAU patients, 41 (40%) patients fulfilled the ASAS classification criteria for axSpA, and 29 (28%) patients were considered highly suggestive of axSpA based on clinical features. Two out of the 55 sacroiliitis-negative patients developed active sacroiliitis at the two-year follow-up. One-third of patients with AAU had active inflammation on SIJ MRI and clinical diagnosis of axSpA. Therefore, patients with AAU, especially those with chronic back pain, should be referred to a rheumatologist, and the examination should be repeated if a new feature of SpA appears.
Sections du résumé
BACKGROUND
BACKGROUND
Acute anterior uveitis (AAU) is a relatively common extra-musculoskeletal manifestation of axial spondyloarthritis (axSpA); however, data on the prevalence of active sacroiliitis in patients with AAU are limited.
METHODS
METHODS
102 patients with AAU and 39 healthy subjects (HS) underwent clinical assessment and sacroiliac joint MRI. Patients with absence of active sacroiliitis were reassessed after two years. International Spondyloarthritis Society (ASAS) classification criteria for axSpA (regardless of patient's age) and expert opinion for definitive diagnosis of axSpA were applied.
RESULTS
RESULTS
Although chronic back pain was equally present in both groups, bone marrow edema (BME) in SIJ and BME highly suggestive of axSpA was found in 52 (51%) and in 33 (32%) patients with AAU compared with 11 (28%) and none in HS, respectively. Out of all AAU patients, 41 (40%) patients fulfilled the ASAS classification criteria for axSpA, and 29 (28%) patients were considered highly suggestive of axSpA based on clinical features. Two out of the 55 sacroiliitis-negative patients developed active sacroiliitis at the two-year follow-up.
CONCLUSIONS
CONCLUSIONS
One-third of patients with AAU had active inflammation on SIJ MRI and clinical diagnosis of axSpA. Therefore, patients with AAU, especially those with chronic back pain, should be referred to a rheumatologist, and the examination should be repeated if a new feature of SpA appears.
Identifiants
pubmed: 35054328
pii: diagnostics12010161
doi: 10.3390/diagnostics12010161
pmc: PMC8774303
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Health
ID : 17-33127A
Organisme : Ministry of Health
ID : 023728
Références
Ann Rheum Dis. 2009 Jun;68 Suppl 2:ii1-44
pubmed: 19433414
RMD Open. 2018 Feb 24;4(1):e000553
pubmed: 29531779
BMC Musculoskelet Disord. 2019 Dec 7;20(1):590
pubmed: 31810455
Ann Rheum Dis. 2019 Nov;78(11):1550-1558
pubmed: 31422357
Semin Ophthalmol. 2017;32(6):689-701
pubmed: 27404944
Front Med (Lausanne). 2018 Apr 17;5:106
pubmed: 29719835
Lancet. 2017 Jul 1;390(10089):73-84
pubmed: 28110981
Ann Rheum Dis. 2011 Jan;70(1):25-31
pubmed: 21109520
Arthritis Rheum. 1984 Apr;27(4):361-8
pubmed: 6231933
Ann Rheum Dis. 2013 Oct;72(10):1646-53
pubmed: 23139266
Ann Rheum Dis. 2008 Jul;67(7):955-9
pubmed: 17962239
Mol Med Rep. 2017 Apr;15(4):1943-1951
pubmed: 28259985
Ann Rheum Dis. 2015 Nov;74(11):1990-5
pubmed: 24928841
Arthritis Rheumatol. 2015 Jan;67(1):140-51
pubmed: 25200001
J Rheumatol. 2017 Dec;44(12):1833-1840
pubmed: 29093157
Ann Rheum Dis. 2011 Aug;70(8):1369-74
pubmed: 21622969
Ophthalmology. 2016 Aug;123(8):1632-1636
pubmed: 27084561
Arthritis Rheum. 1991 Oct;34(10):1218-27
pubmed: 1930310
Scand J Rheumatol. 2009 Mar-Apr;38(2):84-90
pubmed: 18821178
J Rheumatol. 1996 Feb;23(2):407
pubmed: 8882063
Rheumatology (Oxford). 2021 Jun 18;60(6):2725-2734
pubmed: 33216939
J Rheumatol Suppl. 2015 Nov;93:27-9
pubmed: 26523051
Ann Rheum Dis. 2009 Dec;68(12):1811-8
pubmed: 19060001
Ann Rheum Dis. 2009 Oct;68(10):1520-7
pubmed: 19454404
Z Rheumatol. 2009 Sep;68(7):591-3
pubmed: 19680669