Potential Use of CTCs as Biomarkers in Renal Cancer Patients.
CTC
CellCollector
MUC1
RCC
circulating tumor cells
mucin
renal carcinoma
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
09 Jan 2022
09 Jan 2022
Historique:
received:
15
11
2021
revised:
22
12
2021
accepted:
07
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
We demonstrated that the CellCollector is an appropriate tool for detecting CTCs in RCC patients. We examined EpCAM and MUC1 expression levels in RCC tissues and cell lines and analyzed the detection rate of CTCs in blood samples ex vivo using an anti-EpCAM antibody-covered straight or spiraled CellCollector. Eight matched samples were examined for affinity to the anti-EpCAM vs. anti-EpCAM/anti-MUC1 antibody-covered wire. The use of this combination of antibodies allowed us to classify patients with lung metastasis. Finally, four patients were analyzed in vivo. In conclusion, both straight (ex vivo, in vivo) and spiraled (ex vivo) wires detected CTCs.
Identifiants
pubmed: 35054482
pii: life12010089
doi: 10.3390/life12010089
pmc: PMC8779819
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : GILUPI (Germany)
ID : no available
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