Epidermal Barrier Function and Skin Homeostasis in Atopic Dermatitis: The Impact of Age.
aging
atopic dermatitis
skin barrier
stratum corneum
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
17 Jan 2022
17 Jan 2022
Historique:
received:
21
12
2021
revised:
03
01
2022
accepted:
15
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Skin is damaged in atopic dermatitis (AD) patients. Age is also believed to have a negative effect on epidermal barrier function. The aim of this study was to investigate skin barrier function changes with age in AD patients. A cross-sectional study was conducted including 162 participants, 81 AD patients and 81 healthy volunteers. Skin barrier function parameters, such as transepidermal water loss (TEWL), erythema, temperature, stratum corneum hydration (SCH), pH, and elasticity, were evaluated. Healthy volunteers were evaluated on the volar forearm. AD patients were measured on two regions: on an eczematous lesion on the volar forearm and on a non-involved area 5 cm from the affected area. TEWL was lower on healthy skin than uninvolved AD skin (9.98 vs. 25.51 g·m
Identifiants
pubmed: 35054525
pii: life12010132
doi: 10.3390/life12010132
pmc: PMC8779900
pii:
doi:
Types de publication
Journal Article
Langues
eng
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