The Unique Carboxymethyl Fenugreek Gum Gel Loaded Itraconazole Self-Emulsifying Nanovesicles for Topical Onychomycosis Treatment.

anti-fungal itraconazole onychomycosis self-emulsifying nanovesicles transungual

Journal

Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357

Informations de publication

Date de publication:
14 Jan 2022
Historique:
received: 17 12 2021
revised: 07 01 2022
accepted: 11 01 2022
entrez: 21 1 2022
pubmed: 22 1 2022
medline: 22 1 2022
Statut: epublish

Résumé

The novel itraconazole (ITZ) nail penetration enhancing self-emulsifying nanovesicles (ITZ-nPEVs) loaded in carboxymethyl fenugreek gum (CMFG) gel circumvent the systemic onychomycosis treatment. The ITZ-nPEVs were prepared by the thin film hydration technique, and the particle size (PS), zeta potential (ZP), drug content (DC), entrapment efficiency (% EE), deformity index (DI), viscosity, morphology, and physical stability of the ITZ-nPEVs were measured. In terms of nail hydration, transungual drug absorption, and antifungal efficacy against

Identifiants

pubmed: 35054731
pii: polym14020325
doi: 10.3390/polym14020325
pmc: PMC8779379
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Ali Alqahtani (A)

Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia.

Bhavana Raut (B)

Institute of Pharmaceutical Education and Research, Borgaon (Meghe) Wardha, Wardha 442001, India.

Shagufta Khan (S)

Institute of Pharmaceutical Education and Research, Borgaon (Meghe) Wardha, Wardha 442001, India.

Jamal Moideen Muthu Mohamed (JMM)

College of Pharmacy, Shri Indra Ganesan Institute of Medical Science, Tiruchirapalli 620012, India.

Adel Al Fatease (AA)

Department of Pharmaceutics, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia.

Taha Alqahtani (T)

Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia.

Ali Alamri (A)

Department of Pharmaceutics, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia.

Fazil Ahmad (F)

Department of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal University, Dammam 34212, Saudi Arabia.

Venkatesan Krishnaraju (V)

Department of Pharmacology, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, Saudi Arabia.

Classifications MeSH