Where Are We with RPE Replacement Therapy? A Translational Review from the Ophthalmologist Perspective.
Stargardt disease
age related macular degeneration
embryonic stem cells
induced pluripotent stem cells
replacement
retinal pigmented epithelium
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jan 2022
08 Jan 2022
Historique:
received:
10
12
2021
revised:
28
12
2021
accepted:
30
12
2021
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
23
2
2022
Statut:
epublish
Résumé
The retinal pigmented epithelium (RPE) plays a pivotal role in retinal homeostasis. It is therefore an interesting target to fill the unmet medical need of different retinal diseases, including age-related macular degeneration and Stargardt disease. RPE replacement therapy may use different cellular sources: induced pluripotent stem cells or embryonic stem cells. Cells can be transferred as suspension on a patch with different surgical approaches. Results are promising although based on very limited samples. In this review, we summarize the current progress of RPE replacement and provide a comparative assessment of different published approaches which may become standard of care in the future.
Identifiants
pubmed: 35054869
pii: ijms23020682
doi: 10.3390/ijms23020682
pmc: PMC8775975
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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