MicroRNAs as Modulators of the Immune Response in T-Cell Acute Lymphoblastic Leukemia.
Animals
Biomarkers, Tumor
Disease Progression
Disease Susceptibility
Gene Expression Regulation, Leukemic
Humans
Immunomodulation
/ genetics
MicroRNAs
/ genetics
Myeloid-Derived Suppressor Cells
/ immunology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/ diagnosis
RNA Interference
T-Lymphocyte Subsets
/ immunology
Transcription, Genetic
Tumor Microenvironment
/ genetics
Acute lymphoblastic leukaemia
MDSC
Natural Killer cells
Notch
T and regulatory T cells
microRNA
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 Jan 2022
13 Jan 2022
Historique:
received:
03
12
2021
revised:
23
12
2021
accepted:
10
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
4
2
2022
Statut:
epublish
Résumé
Acute lymphoblastic leukaemia (ALL) is an aggressive haematological tumour driven by the malignant transformation and expansion of B-cell (B-ALL) or T-cell (T-ALL) progenitors. The evolution of T-ALL pathogenesis encompasses different master developmental pathways, including the main role played by Notch in cell fate choices during tissue differentiation. Recently, a growing body of evidence has highlighted epigenetic changes, particularly the altered expression of microRNAs (miRNAs), as a critical molecular mechanism to sustain T-ALL. The immune response is emerging as key factor in the complex multistep process of cancer but the role of miRNAs in anti-leukaemia response remains elusive. In this review we analyse the available literature on miRNAs as tuners of the immune response in T-ALL, focusing on their role in Natural Killer, T, T-regulatory and Myeloid-derived suppressor cells. A better understanding of this molecular crosstalk may provide the basis for the development of potential immunotherapeutic strategies in the leukemia field.
Identifiants
pubmed: 35055013
pii: ijms23020829
doi: 10.3390/ijms23020829
pmc: PMC8776227
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
MicroRNAs
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Education, University and Research - Dipartimenti di Eccellenza
ID : L. 232/2016
Organisme : Sapienza University of Rome
ID : RP11916B88BC2710
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