The Broad-Spectrum Antiviral Potential of the Amphibian Peptide AR-23.
Amphibian Proteins
/ pharmacology
Animals
Antimicrobial Cationic Peptides
/ pharmacology
Antimicrobial Peptides
/ pharmacology
Antiviral Agents
/ pharmacology
Cell Survival
/ drug effects
Chlorocebus aethiops
DNA Viruses
/ drug effects
RNA Viruses
/ drug effects
Ranidae
/ metabolism
SARS-CoV-2
/ drug effects
Vero Cells
Viral Envelope
/ drug effects
Viral Plaque Assay
Virus Diseases
/ drug therapy
HSV-1
SARS-CoV-2
antimicrobial peptides
antiviral drugs
antiviral therapy
coronavirus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Jan 2022
14 Jan 2022
Historique:
received:
11
12
2021
revised:
10
01
2022
accepted:
11
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
29
1
2022
Statut:
epublish
Résumé
Viral infections represent a serious threat to the world population and are becoming more frequent. The search and identification of broad-spectrum antiviral molecules is necessary to ensure new therapeutic options, since there is a limited availability of effective antiviral drugs able to eradicate viral infections, and consequently due to the increase of strains that are resistant to the most used drugs. Recently, several studies on antimicrobial peptides identified them as promising antiviral agents. In detail, amphibian skin secretions serve as a rich source of natural antimicrobial peptides. Their antibacterial and antifungal activities have been widely reported, but their exploitation as potential antiviral agents have yet to be fully investigated. In the present study, the antiviral activity of the peptide derived from the secretion of
Identifiants
pubmed: 35055066
pii: ijms23020883
doi: 10.3390/ijms23020883
pmc: PMC8779559
pii:
doi:
Substances chimiques
AR-23 peptide, Rana fagoi
0
Amphibian Proteins
0
Antimicrobial Cationic Peptides
0
Antimicrobial Peptides
0
Antiviral Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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