Controlled Liposome Delivery from Chitosan-Based Thermosensitive Hydrogel for Regenerative Medicine.
controlled delivery
extracellular vesicles
liposome
regenerative medicine
thermosensitive hydrogel
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 Jan 2022
14 Jan 2022
Historique:
received:
11
12
2021
revised:
11
01
2022
accepted:
12
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
8
2
2022
Statut:
epublish
Résumé
This work describes the development of an injectable nanocomposite system based on a chitosan thermosensitive hydrogel combined with liposomes for regenerative medicine applications. Liposomes with good physicochemical properties are prepared and embedded within the chitosan network. The resulting nanocomposite hydrogel is able to provide a controlled release of the content from liposomes, which are able to interact with cells and be internalized. The cellular uptake is enhanced by the presence of a chitosan coating, and cells incubated with liposomes embedded within thermosensitive hydrogels displayed a higher cell uptake compared to cells incubated with liposomes alone. Furthermore, the gelation temperature of the system resulted to be equal to 32.6 °C; thus, the system can be easily injected in the target site to form a hydrogel at physiological temperature. Given the peculiar performance of the selected systems, the resulting thermosensitive hydrogels are a versatile platform and display potential applications as controlled delivery systems of liposomes for tissue regeneration.
Identifiants
pubmed: 35055097
pii: ijms23020894
doi: 10.3390/ijms23020894
pmc: PMC8776110
pii:
doi:
Substances chimiques
Drug Carriers
0
Hydrogels
0
Liposomes
0
Chitosan
9012-76-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Minister of Defense (n.)
ID : MIS-RIGENERA, 14_25.11.2019
Références
J Extracell Vesicles. 2015 Feb 09;4:26238
pubmed: 25669322
Biomaterials. 2000 Nov;21(21):2155-61
pubmed: 10985488
Nanotechnology. 2008 Feb 20;19(7):075105
pubmed: 21817630
Mar Drugs. 2015 Aug 14;13(8):5156-86
pubmed: 26287217
Biomed Microdevices. 2015 Oct;17(5):84
pubmed: 26233725
Br J Cancer. 2017 Feb 28;116(5):609-619
pubmed: 28152544
Chem Soc Rev. 2012 Mar 21;41(6):2193-221
pubmed: 22116474
J Control Release. 2004 Nov 5;100(1):5-28
pubmed: 15491807
Adv Drug Deliv Rev. 2021 Aug;175:113801
pubmed: 34015418
Int J Mol Sci. 2017 May 29;18(6):
pubmed: 28555055
Gels. 2018 Aug 09;4(3):
pubmed: 30674843
Int J Pharm. 2018 Oct 25;550(1-2):100-113
pubmed: 30138707
J Liposome Res. 2021 Dec;31(4):356-364
pubmed: 32901526
Artif Cells Nanomed Biotechnol. 2016;44(1):381-91
pubmed: 25222036
ACS Nano. 2021 Jun 28;:
pubmed: 34181394
Stem Cell Res Ther. 2013;4(5):117
pubmed: 24073831
Science. 2017 May 5;356(6337):
pubmed: 28473537
Biol Res. 2016 Jul 04;49(1):32
pubmed: 27378167
J Biomater Sci Polym Ed. 2013;24(14):1649-59
pubmed: 23607789
J Food Drug Anal. 2015 Dec;23(4):619-629
pubmed: 28911477
J Am Chem Soc. 2016 Jan 27;138(3):704-17
pubmed: 26741786
Langmuir. 2013 Aug 13;29(32):10229-37
pubmed: 23865795
Compr Rev Food Sci Food Saf. 2021 Mar;20(2):1280-1306
pubmed: 33665991
Biomaterials. 2002 Jul;23(13):2717-22
pubmed: 12059021
Biomaterials. 2013 Jul;34(21):5369-80
pubmed: 23615561
Molecules. 2016 Nov 21;21(11):
pubmed: 27879635
Biomaterials. 2014 Jun;35(18):4969-85
pubmed: 24674460
ACS Appl Mater Interfaces. 2019 Mar 13;11(10):9794-9803
pubmed: 30768897
ACS Nano. 2015 Jun 23;9(6):5725-40
pubmed: 26004286
Biomaterials. 2010 May;31(14):3976-85
pubmed: 20170955
Biomacromolecules. 2014 Sep 8;15(9):3396-405
pubmed: 25133954
Int J Mol Sci. 2020 Jul 09;21(14):
pubmed: 32659908
Adv Drug Deliv Rev. 2020;159:332-343
pubmed: 32305351
Adv Healthc Mater. 2021 Jun 24;:e2100639
pubmed: 34165909
Biotechnol Bioeng. 2009 Jul 1;103(4):655-63
pubmed: 19472329
Tissue Eng. 2001 Dec;7(6):729-41
pubmed: 11749730
Carbohydr Polym. 2015 Mar 6;117:524-536
pubmed: 25498667
Stem Cell Res Ther. 2019 Jan 31;10(1):47
pubmed: 30704535
ACS Appl Mater Interfaces. 2018 Apr 4;10(13):10761-10770
pubmed: 29569895
Molecules. 2020 Dec 01;25(23):
pubmed: 33271886
J Control Release. 2015 Feb 10;199:145-55
pubmed: 25523519
Bioimpacts. 2014;4(3):149-66
pubmed: 25337468
Expert Opin Drug Deliv. 2014 Feb;11(2):249-67
pubmed: 24304097
Eur J Pharm Biopharm. 2014 Oct;88(2):361-73
pubmed: 24859306
J Liposome Res. 2019 Dec;29(4):313-321
pubmed: 29685077
Colloids Surf B Biointerfaces. 2018 Oct 1;170:718-728
pubmed: 30005409
Nanoscale Res Lett. 2013 Feb 22;8(1):102
pubmed: 23432972
World J Gastroenterol. 2002 Jun;8(3):385-92
pubmed: 12046056
Nat Rev Drug Discov. 2005 Feb;4(2):145-60
pubmed: 15688077