The Effects of SARS-CoV-2 Infection on Female Fertility: A Review of the Literature.
COVID-19
SARS-CoV-2
embryos
endometrium
female reproductive system
follicular fluid
in vitro fertilization
menstrual cycle
oocytes
ovarian reserve
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
16 Jan 2022
16 Jan 2022
Historique:
received:
17
12
2021
revised:
10
01
2022
accepted:
14
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
29
1
2022
Statut:
epublish
Résumé
As the coronavirus pandemic is far from ending, more questions regarding the female reproductive system, particularly fertility issues, arise. The purpose of this paper is to bring light upon the possible link between COVID-19 and women's reproductive health. This review emphasizes the effect of SARS-CoV-2 on the hormones, endometrium and menstrual cycle, ovarian reserve, follicular fluid, oocytes, and embryos. The results showed that endometrial samples did not express SARS-CoV-2 RNA. Regarding the menstrual cycle, there is a large range of alterations, but they were all reversible within the following months. The ovarian reserve was not significantly affected in patients recovering from both mild and severe infection in most cases, except one, where the levels of AMH were significantly lower and basal follicle-stimulating hormone (FSH) levels were increased. All COVID-19 recovered patients had positive levels of SARS-CoV-2 IgG in the follicular fluid. The amount of retrieved and mature oocytes and the fertilization rate were unharmed in three studies, except for one study, where the quantity of retrieved and mature oocytes was reduced in patients with higher levels of SARS-CoV-2 antibodies. The numbers of blastocysts, top-quality embryos, and euploid embryos were affected in most of the studies reviewed.
Identifiants
pubmed: 35055804
pii: ijerph19020984
doi: 10.3390/ijerph19020984
pmc: PMC8775865
pii:
doi:
Substances chimiques
RNA, Viral
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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