The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains.
GABA
NMDA
anticonvulsant
metabolomics
neurosteroids
zuranolone
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
30 Dec 2021
30 Dec 2021
Historique:
received:
30
11
2021
revised:
21
12
2021
accepted:
27
12
2021
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo. Our in vitro experiments identified PA-G as an inhibitor of
Identifiants
pubmed: 35056106
pii: ph15010049
doi: 10.3390/ph15010049
pmc: PMC8780580
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : European Regional Development Fund
ID : ERDF/ESF Project "PharmaBrain" No. CZ.02.1.01/0.0/0.0/16_025/0007444
Organisme : Czech Academy of Sciences
ID : grant RVO 61388963
Organisme : Czech Academy of Sciences
ID : Programs of Strategy AV21
Organisme : Czech Academy of Sciences
ID : 18-09296S
Organisme : Internal Grant Agency of Czech Republic
ID : NU20-04-00389
Références
Int Rev Neurobiol. 2001;46:1-32
pubmed: 11599297
Epilepsy Res. 1987 Sep;1(5):302-5
pubmed: 3504406
J Reprod Fertil. 1991 Nov;93(2):609-22
pubmed: 1787481
Sci Transl Med. 2014 Nov 12;6(262):262ps13
pubmed: 25391480
Front Behav Neurosci. 2014 Apr 16;8:130
pubmed: 24795582
Epilepsia. 2020 Sep;61(9):e129-e134
pubmed: 32929741
Neurosci Lett. 2014 Apr 3;564:11-5
pubmed: 24513236
Neuropharmacology. 2016 Apr;103:163-73
pubmed: 26626485
Ann Neurol. 2017 Sep;82(3):342-352
pubmed: 28779545
Front Cell Neurosci. 2016 Apr 22;10:101
pubmed: 27147973
Pharmacol Biochem Behav. 2005 Dec;82(4):712-20
pubmed: 16388839
J Med Chem. 2015 Aug 13;58(15):5950-66
pubmed: 26171651
J Neuroendocrinol. 2018 Nov;30(11):e12644
pubmed: 30194779
Endocrinology. 1997 Aug;138(8):3166-74
pubmed: 9231764
J Chromatogr Sci. 2000 Jan;38(1):6-10
pubmed: 10654785
Brain Res Bull. 2013 Apr;93:39-46
pubmed: 23174309
J Neurosci. 2005 Sep 14;25(37):8439-50
pubmed: 16162926
Epilepsia Open. 2018 Nov 02;3(Suppl Suppl 2):165-168
pubmed: 30564775
J Neurochem. 2018 Oct;147(2):275-284
pubmed: 30005125
Cell. 2020 Jun 25;181(7):1680-1692.e15
pubmed: 32589958
Fertil Steril. 2005 Sep;84(3):701-10
pubmed: 16169406
Front Pharmacol. 2018 Apr 11;9:354
pubmed: 29695968
J Chromatogr B Biomed Sci Appl. 2000 Mar 10;739(2):301-12
pubmed: 10755374
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jul 1;35(5):1178-91
pubmed: 21216265
Mol Pharmacol. 1997 Dec;52(6):1113-23
pubmed: 9396781
Br J Pharmacol. 2012 Jun;166(3):1069-83
pubmed: 22188257
J Med Chem. 2017 Sep 28;60(18):7810-7819
pubmed: 28753313
J Steroid Biochem Mol Biol. 2016 Jun;160:181-8
pubmed: 26365557
Neuroscience. 2006;138(3):757-64
pubmed: 16310315
Brain Res Dev Brain Res. 2001 Nov 26;131(1-2):31-9
pubmed: 11718833
Neuroendocrinology. 2008;88(4):287-92
pubmed: 18552483
Metabolism. 1967 Feb;16(2):153-61
pubmed: 6018960
J Endocrinol. 2009 Jul;202(1):99-109
pubmed: 19403566
J Steroid Biochem Mol Biol. 1992 Dec;43(8):1095-8
pubmed: 22217854
Anal Chem. 2003 Nov 1;75(21):5835-46
pubmed: 14588024
J Steroid Biochem. 1977 Nov;8(11):1197-9
pubmed: 926788
Eur J Neurosci. 2003 Sep;18(6):1458-67
pubmed: 14511326
Neuropharmacology. 2011 Jul-Aug;61(1-2):61-8
pubmed: 21354187
Biopharm Drug Dispos. 2009 Nov;30(8):411-21
pubmed: 19746353
J Steroid Biochem Mol Biol. 1997 Jul;62(4):299-306
pubmed: 9408083
Endocrinology. 2006 Jan;147(1):179-90
pubmed: 16223859
Pharmaceutics. 2021 Jun 04;13(6):
pubmed: 34199715
Neuroendocrinology. 2006;84(4):264-74
pubmed: 17164539
J Physiol. 2015 Jan 1;593(1):267-84
pubmed: 25556800
J Steroid Biochem Mol Biol. 1999 Sep-Oct;70(4-6):159-67
pubmed: 10622404
J Neurochem. 2017 Sep;142(5):672-685
pubmed: 28665486
Neurochem Int. 2018 Feb;113:46-55
pubmed: 29162485
Epilepsia. 2016 Mar;57(3):343-7
pubmed: 26778176
Neuroscience. 2011 Sep 15;191:22-7
pubmed: 21641969
Adv Pharmacol. 2014;71:361-90
pubmed: 25307223
J Steroid Biochem Mol Biol. 2007 Jun-Jul;105(1-5):166-75
pubmed: 17583491
Epilepsia. 2013 Nov;54 Suppl 8:34-7
pubmed: 24571115
Am J Physiol. 1971 Feb;220(2):333-6
pubmed: 5540880
Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):85-8
pubmed: 8419947
J Steroid Biochem Mol Biol. 2002 Nov;82(4-5):377-84
pubmed: 12589945
Brain Res. 1999 May 29;830(1):72-87
pubmed: 10350561
Physiol Res. 2019 Apr 30;68(2):179-207
pubmed: 31037947
Biochem Pharmacol. 2004 Sep 1;68(5):819-31
pubmed: 15294445
Endocr Rev. 2019 Apr 1;40(2):447-475
pubmed: 30137266
Neuroendocrinology. 2021;111(6):536-541
pubmed: 32492675
Biomolecules. 2021 Jul 14;11(7):
pubmed: 34356650
Neurochem Int. 2008 Mar-Apr;52(4-5):602-10
pubmed: 17850922
J Pharmacol Exp Ther. 2000 Jun;293(3):747-54
pubmed: 10869372
Int J Mol Sci. 2020 Dec 10;21(24):
pubmed: 33321734
Biomol Concepts. 2013 Feb;4(1):29-42
pubmed: 25436563
Neurosci Lett. 2021 Apr 17;750:135771
pubmed: 33636284
Neuropharmacology. 2021 Feb 1;183:108358
pubmed: 33115614
JAMA Psychiatry. 2021 Sep 1;78(9):951-959
pubmed: 34190962
J Exp Pharmacol. 2021 Mar 08;13:235-244
pubmed: 33727865
Eur J Endocrinol. 2021 Mar;184(3):R85-R97
pubmed: 33320831
Biomolecules. 2020 Mar 18;10(3):
pubmed: 32197322
Clin Chim Acta. 1960 May;5:396-405
pubmed: 13798513
Neurochem Int. 2018 Sep;118:145-151
pubmed: 29886074
PLoS Biol. 2019 Apr 3;17(4):e3000198
pubmed: 30943210
Bioorg Med Chem Lett. 2018 Jan 15;28(2):61-70
pubmed: 29223589
J Nutr. 2007 May;137(5):1149-53
pubmed: 17449573