SGC-CK2-1 Is an Efficient Inducer of Insulin Production and Secretion in Pancreatic β-Cells.
CX-4945
SGC-CK2-1
insulin
pancreatic β-cells
protein kinase CK2
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
22 Dec 2021
22 Dec 2021
Historique:
received:
25
11
2021
revised:
17
12
2021
accepted:
20
12
2021
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
The pyrazolopyrimidine based compound SGC-CK2-1 is a potent and highly specific CK2 inhibitor and a new tool to study the biological functions of protein kinase CK2 irrespective from off-target effects. We used this compound in comparison with the well-established CK2 inhibitor CX-4945 to analyze the importance of CK2 for insulin production and secretion from pancreatic β-cells. Both inhibitors affected the proliferation and viability of MIN6 cells only marginally and downregulated the endogenous CK2 activity to a similar level. Furthermore, both inhibitors increased the message for insulin and boosted the secretion of insulin from storage vesicles. Thus, regarding the high specificity of SGC-CK2-1, we can clearly attribute the observed effects to biological functions of protein kinase CK2.
Identifiants
pubmed: 35056914
pii: pharmaceutics14010019
doi: 10.3390/pharmaceutics14010019
pmc: PMC8778508
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Dr. Rolf M. Schwiete Stiftung
ID : 2020-006
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