Prenatal Folate and Choline Levels and Brain and Cognitive Development in Children: A Critical Narrative Review.
Animals
Brain
/ growth & development
Child
Child Development
Child, Preschool
Choline
/ administration & dosage
Cognition
Female
Fetal Development
Folic Acid
/ administration & dosage
Humans
Infant
Male
Mice
Nutritional Status
Pregnancy
Prenatal Nutritional Physiological Phenomena
Surveys and Questionnaires
Vitamins
/ administration & dosage
brain development
children
choline
cognitive development
folate
neurodevelopment
pregnancy
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
15 Jan 2022
15 Jan 2022
Historique:
received:
14
12
2021
revised:
12
01
2022
accepted:
13
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
27
1
2022
Statut:
epublish
Résumé
Women's nutritional status during pregnancy can have long-term effects on children's brains and cognitive development. Folate and choline are methyl-donor nutrients and are important for closure of the neural tube during fetal development. They have also been associated with brain and cognitive development in children. Animal studies have observed that prenatal folate and choline supplementation is associated with better cognitive outcomes in offspring and that these nutrients may have interactive effects on brain development. Although some human studies have reported associations between maternal folate and choline levels and child cognitive outcomes, results are not consistent, and no human studies have investigated the potential interactive effects of folate and choline. This lack of consistency could be due to differences in the methods used to assess folate and choline levels, the gestational trimester at which they were measured, and lack of consideration of potential confounding variables. This narrative review discusses and critically reviews current research examining the associations between maternal levels of folate and choline during pregnancy and brain and cognitive development in children. Directions for future research that will increase our understanding of the effects of these nutrients on children's neurodevelopment are discussed.
Identifiants
pubmed: 35057545
pii: nu14020364
doi: 10.3390/nu14020364
pmc: PMC8778665
pii:
doi:
Substances chimiques
Vitamins
0
Folic Acid
935E97BOY8
Choline
N91BDP6H0X
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Demography. 2018 Dec;55(6):2229-2255
pubmed: 30387046
FASEB J. 2010 Jan;24(1):184-95
pubmed: 19752176
Nutrients. 2018 Oct 16;10(10):
pubmed: 30332744
JAMA. 2017 Jan 10;317(2):183-189
pubmed: 28097362
J Nutr. 2010 Jun;140(6):1162-6
pubmed: 20392884
Nutr Rev. 2018 Jul 1;76(7):497-511
pubmed: 29701796
Med Clin North Am. 2016 Nov;100(6):1199-1215
pubmed: 27745590
Am J Clin Nutr. 2012 Dec;96(6):1465-72
pubmed: 23134891
J Alzheimers Dis. 2016 Mar 21;52(2):705-12
pubmed: 27003215
Am J Epidemiol. 2013 Jun 15;177(12):1338-47
pubmed: 23425631
Appl Physiol Nutr Metab. 2014 Dec;39(12):1402-8
pubmed: 25386981
Nat Rev Mol Cell Biol. 2019 Jul;20(7):436-450
pubmed: 30976106
J Comp Neurol. 1997 Oct 20;387(2):167-78
pubmed: 9336221
Annu Rev Nutr. 2006;26:229-50
pubmed: 16848706
Am J Clin Nutr. 2010 Jan;91(1):64-72
pubmed: 19828716
PLoS One. 2017 Dec 15;12(12):e0189230
pubmed: 29244867
MMWR Morb Mortal Wkly Rep. 2015 Apr 24;64(15):421-3
pubmed: 25905896
Am J Clin Nutr. 2007 Mar;85(3):796-802
pubmed: 17344502
Front Hum Neurosci. 2013 Mar 26;7:97
pubmed: 23532379
Matern Child Health J. 2008 Mar;12(2):180-7
pubmed: 17554612
Adv Nutr. 2013 Jan 01;4(1):123-5
pubmed: 23319130
FASEB J. 2018 Apr;32(4):2172-2180
pubmed: 29217669
J Nutr. 2010 May;140(5):1014-22
pubmed: 20335637
Pediatrics. 2009 Apr;123(4):e685-92
pubmed: 19336358
Z Geburtshilfe Neonatol. 1996 Sep-Oct;200(5):176-80
pubmed: 8950836
Am J Clin Nutr. 2007 Sep;86(3):718-27
pubmed: 17823438
FASEB J. 2006 Jan;20(1):43-9
pubmed: 16394266
J Osteoporos. 2013;2013:154109
pubmed: 23781391
Paediatr Perinat Epidemiol. 2012 Jul;26(4):328-35
pubmed: 22686384
Nutrients. 2019 Aug 07;11(8):
pubmed: 31394787
Birth Defects Res A Clin Mol Teratol. 2005 Apr;73(4):249-52
pubmed: 15744731
J Perinat Med. 1985;13(2):55-9
pubmed: 4009385
Hum Mol Genet. 2011 May 1;20(9):1687-96
pubmed: 21296867
Neuroscience. 2015 Aug 6;300:1-9
pubmed: 25956258
Am J Clin Nutr. 1996 Apr;63(4):520-5
pubmed: 8599315
Lancet. 1982 Jul 24;2(8291):217
pubmed: 6123916
Paediatr Perinat Epidemiol. 2018 Jan;32(1):100-111
pubmed: 28984369
Brain Res Dev Brain Res. 1999 Jun 2;115(2):123-9
pubmed: 10407130
Am J Epidemiol. 2004 Jul 15;160(2):102-9
pubmed: 15234930
Eur J Clin Nutr. 2005 Feb;59(2):246-54
pubmed: 15483632
Nutr Rev. 2004 Jun;62(6 Pt 2):S35-9
pubmed: 15298446
Child Indic Res. 2018;11(5):1495-1513
pubmed: 30220940
Crit Rev Food Sci Nutr. 2021 Oct 21;:1-17
pubmed: 34672229
Br J Nutr. 2019 Sep;122(s1):S1-S9
pubmed: 31638501
Brain Res. 2008 Oct 27;1237:124-35
pubmed: 18786520
Pak J Med Sci. 2017 Jan-Feb;33(1):162-166
pubmed: 28367192
J Nutr. 2003 Nov;133(11):3614-8
pubmed: 14608083
Am J Med Genet. 1996 Mar 15;62(2):179-83
pubmed: 8882400
Nutr Rev. 2009 Nov;67(11):615-23
pubmed: 19906248
Appl Neuropsychol Child. 2013;2(2):82-7
pubmed: 23848243
Nutrients. 2019 Feb 20;11(2):
pubmed: 30791647
Am J Clin Nutr. 2015 Jun;101(6):1163-72
pubmed: 25877491
Am J Clin Nutr. 2004 Nov;80(5):1312-21
pubmed: 15531681
Pediatrics. 2005 Sep;116(3):703-8
pubmed: 16140711
Int J Hyg Environ Health. 2019 Apr;222(3):503-512
pubmed: 30713056
Placenta. 2004 Jul;25(6):588-93
pubmed: 15135243
Nat Rev Neurosci. 2005 Jan;6(1):48-56
pubmed: 15611726
Br J Nutr. 1988 Mar;59(2):251-9
pubmed: 3358927
Br J Nutr. 2014 Jul 14;112(1):112-21
pubmed: 24708921
Paediatr Perinat Epidemiol. 2009 May;23(3):199-206
pubmed: 19775381
J Nutr. 2016 Mar;146(3):484-93
pubmed: 26865644
Mol Nutr Food Res. 2011 Jan;55(1):166-80
pubmed: 21207520
J Nutr. 2004 Jan;134(1):162-6
pubmed: 14704311
BMC Med. 2019 Oct 31;17(1):196
pubmed: 31672132
J Pediatr. 2003 Oct;143(4 Suppl):S35-45
pubmed: 14597912
J Pediatr Psychol. 2008 Oct;33(9):999-1014; discussion 1015-20
pubmed: 18194973
Birth Defects Res A Clin Mol Teratol. 2008 Sep;82(9):622-6
pubmed: 18655127
Br J Haematol. 1975 Mar;29(3):469-78
pubmed: 1191558
Sci Total Environ. 2018 Jan 1;610-611:741-749
pubmed: 28822941
JAMA. 2017 Jan 10;317(2):190-203
pubmed: 28097361
Nutrients. 2015 Mar 10;7(3):1744-68
pubmed: 25763532
Br J Obstet Gynaecol. 1992 Jan;99(1):23-5
pubmed: 1547166
J Nutr. 2004 Jul;134(7):1800-5
pubmed: 15226472
Nutr Neurosci. 2009 Oct;12(5):226-32
pubmed: 19761653
Brain Res. 2008 Oct 27;1237:110-23
pubmed: 18786518
Adv Nutr. 2019 May 1;10(3):502-519
pubmed: 31093652
Am J Clin Nutr. 2019 May 1;109(5):1452-1461
pubmed: 31005964
Neurochem Res. 1998 May;23(5):751-8
pubmed: 9566615
Pediatr Rev. 2010 Sep;31(9):364-7
pubmed: 20810700
Nutrients. 2017 Nov 20;9(11):
pubmed: 29156647
Basic Clin Neurosci. 2019 Mar-Apr;10(2):165-174
pubmed: 31031903
Sci Rep. 2019 Jun 6;9(1):8347
pubmed: 31171831
BMC Pregnancy Childbirth. 2007 Oct 25;7:25
pubmed: 17961229
PLoS One. 2014 Feb 19;9(2):e89354
pubmed: 24586711
Neuroreport. 1997 Sep 29;8(14):3053-9
pubmed: 9331913
Neuroradiology. 2013 Sep;55 Suppl 2:23-40
pubmed: 23832006
Br J Nutr. 2006 Nov;96(5):913-20
pubmed: 17092382
Dev Psychobiol. 1988 May;21(4):339-53
pubmed: 3378679
Am J Psychiatry. 2013 Mar;170(3):290-8
pubmed: 23318559
Am J Clin Nutr. 2005 Oct;82(4):836-42
pubmed: 16210714
Nutrients. 2017 Jul 28;9(8):
pubmed: 28788094
J Nutr. 2003 Mar;133 Suppl 3:881S-887S
pubmed: 12612174
Eur J Neurosci. 2007 Apr;25(8):2473-82
pubmed: 17445242
Epidemiology. 2009 Sep;20(5):714-9
pubmed: 19593156
Am J Clin Nutr. 2008 Apr;87(4):896-902
pubmed: 18400712
J Pediatr. 2006 Nov;149(5 Suppl):S131-6
pubmed: 17212955
J Neurochem. 1980 Jan;34(1):147-52
pubmed: 7452231
Neurosci Biobehav Rev. 2003 Sep;27(4):385-99
pubmed: 12946691
Public Health Nutr. 2012 Sep;15(9):1728-36
pubmed: 22314109
Am J Clin Nutr. 2007 Feb;85(2):598S-603S
pubmed: 17284762
Brain Res Dev Brain Res. 1999 Dec 10;118(1-2):51-9
pubmed: 10611503
J Am Coll Nutr. 2002 Feb;21(1):33-7
pubmed: 11838885
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):12834-9
pubmed: 20624989
Neuroreport. 1997 Sep 29;8(14):3045-51
pubmed: 9331912
Nutr Rev. 2003 Dec;61(12):413-22
pubmed: 14968911
Br J Nutr. 2001 May;85 Suppl 2:S139-45
pubmed: 11509102
Am J Clin Nutr. 2007 Feb;85(2):614S-620S
pubmed: 17284765
PLoS One. 2012;7(8):e43448
pubmed: 22916264
Dev Psychol. 2011 Jul;47(4):984-90
pubmed: 21744957
Am J Clin Nutr. 2005 Jul;82(1):133-9
pubmed: 16002811
Behav Sci (Basel). 2020 Oct 17;10(10):
pubmed: 33080874