Discovery of B-cell epitopes for development of dengue vaccines and antibody therapeutics.
B-cell epitope
Dengue virus
Envelope glycoprotein
Therapeutic antibody
Vaccine
Journal
Medical microbiology and immunology
ISSN: 1432-1831
Titre abrégé: Med Microbiol Immunol
Pays: Germany
ID NLM: 0314524
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
21
07
2021
accepted:
04
12
2021
pubmed:
22
1
2022
medline:
24
2
2022
entrez:
21
1
2022
Statut:
ppublish
Résumé
Dengue is one of the most frequently transmitted viral infections globally which creates a serious burden to the healthcare system in many countries in the tropical and subtropical regions. To date, no vaccine has demonstrated balanced protection against the four dengue serotypes. Dengvaxia as the only vaccine that has been licensed for use in endemic areas has shown an increased risk in dengue-naïve vaccines to develop severe dengue. A crucial element in protection from dengue infection is the neutralizing antibody responses. Therefore, the identification of protective linear B-cell epitopes can guide vaccine design and facilitate the development of monoclonal antibodies as dengue therapeutics. This review summarizes the identification of dengue B-cell epitopes within the envelope (E) protein of dengue that can be incorporated into peptide vaccine constructs. These epitopes have been identified through approaches such as bioinformatics, three-dimensional structure analysis of antibody-dengue complexes, mutagenesis/alanine scanning and escape mutant studies. Additionally, the therapeutic potential of monoclonal antibodies targeting the E protein of dengue is reviewed. This can provide a basis for the design of future dengue therapies.
Identifiants
pubmed: 35059822
doi: 10.1007/s00430-021-00726-1
pii: 10.1007/s00430-021-00726-1
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Dengue Vaccines
0
Epitopes, B-Lymphocyte
0
Viral Envelope Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-18Subventions
Organisme : ministry of education, malaysia
ID : FRGS/1/2020/SKK06/SYUC/03/1
Organisme : sunway university
ID : IRG2021
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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