Biomarkers involved in the proliferation of the odontogenic keratocyst, glandular odontogenic cyst and botryoid odontogenic cyst.
Cyclin D1
Epidermal growth factor receptor
Odontogenic cysts
SOX2 protein
Journal
Oral and maxillofacial surgery
ISSN: 1865-1569
Titre abrégé: Oral Maxillofac Surg
Pays: Germany
ID NLM: 101319632
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
01
08
2021
accepted:
10
12
2021
pubmed:
22
1
2022
medline:
11
11
2022
entrez:
21
1
2022
Statut:
ppublish
Résumé
Odontogenic cysts are a heterogeneous group of lesions with varied clinical behavior. To analyze the expression of the epidermal growth factor receptor (EGFR), Cyclin D1, and transcription factor SOX2 in the odontogenic epithelium evaluating the cell cycle control and cystic expansion. This was a cross-sectional study including 40 cases, 20 odontogenic keratocysts (OKC), 10 botryoid odontogenic cysts (BOC), and 10 glandular odontogenic cysts (GOC). All cases of OKC, BOC, and GOC were positive for EGFR in all layers of the cyst lining. The highest expression of nuclear Cyclin D1 was observed in the suprabasal layer of OKCs and in the basal and suprabasal layers of GOC and BOC (p < 0.001). In addition, SOX2 was only expressed in the suprabasal layer of OKCs. The high expression of EGFR in the cyst membrane suggests that EGF stimulates epithelial proliferation in BOCs, and the high expression of SOX2 in OKCs may be related to the presence of stem cells in the lesion. Cyclin D1 is related to cell cycle disruption in G1-S contributing to stimulates epithelial proliferation of OKCs and GOCs and BOCs.
Identifiants
pubmed: 35059898
doi: 10.1007/s10006-021-01026-x
pii: 10.1007/s10006-021-01026-x
doi:
Substances chimiques
Cyclin D1
136601-57-5
Biomarkers
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
655-662Subventions
Organisme : coordenação de aperfeiçoamento de pessoal de nível superior
ID : 001
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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