Effect of age, sex, and breed on serum cystatin C and creatinine concentrations in dogs.
Age
Creatinine
Cystatin C
Dog breed
Sex
Journal
Veterinary research communications
ISSN: 1573-7446
Titre abrégé: Vet Res Commun
Pays: Switzerland
ID NLM: 8100520
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
26
03
2021
accepted:
30
09
2021
pubmed:
22
1
2022
medline:
29
1
2022
entrez:
21
1
2022
Statut:
ppublish
Résumé
This study investigated the effects of age, sex and breed on serum cystatin C (Cys-C) and creatinine in small breed dogs. This retrospective study included 250 dogs weighing less than 15 kg without azotemia. Serum Cys-C and creatinine concentrations were analyzed, along with their correlation with age, and the difference between sexes or dog breeds. Serum Cys-C concentration correlated with age (P < 0.001), and did not differ between sexes or dog breeds. By contrast, serum creatinine concentration did not correlate with age. Serum creatinine concentration was higher in males than females (P < 0.05), and was lower in Miniature Dachshunds and Chihuahuas, and was higher in Shiba Inus compared to the general study population (P < 0.001). Serum Cys-C concentration correlates with age, and might be more sensitive to aging-associated subclinical renal dysfunction than serum creatinine concentration in dogs. Unlike serum creatinine concentration, serum Cys-C concentration is not affected by sex or dog breed.
Identifiants
pubmed: 35061167
doi: 10.1007/s11259-021-09844-w
pii: 10.1007/s11259-021-09844-w
doi:
Substances chimiques
Biomarkers
0
Cystatin C
0
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
183-188Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature B.V.
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