Analysis of oxidative degradation and calcification behavior of a silicone polycarbonate polyurethane-polydimethylsiloxane material.


Journal

Journal of biomedical materials research. Part A
ISSN: 1552-4965
Titre abrégé: J Biomed Mater Res A
Pays: United States
ID NLM: 101234237

Informations de publication

Date de publication:
05 2022
Historique:
revised: 22 10 2021
received: 12 03 2021
accepted: 20 12 2021
pubmed: 22 1 2022
medline: 26 4 2022
entrez: 21 1 2022
Statut: ppublish

Résumé

The biocompatibility and chemical stability of implantable devices are crucial for their long-term success. CarboSil® is a silicon polycarbonate polyurethane copolymer with good biocompatibility and biostability properties. Here, we explored the possibility to improve these characteristics by introducing 30% of extra-chain cross-linkable poly(dimethyl siloxane) (PDMS). Patches made of CarboSil and CarboSil-30% PDMS were manufactured by spray, phase-inversion technique and subjected to a heating-pressure treatment. Both materials showed good biocompatibility, either in viability and proliferation of cell-based experiments both with mouse fibroblasts and subcutaneous implant in rats. Fourier-transform infrared spectroscopy showed a significant decrease in soft segment loss in CarboSil-30% PDMS samples with respect to CarboSil in in vitro accelerated oxidative treatments with CoCl

Identifiants

pubmed: 35061325
doi: 10.1002/jbm.a.37357
doi:

Substances chimiques

Biocompatible Materials 0
Dimethylpolysiloxanes 0
Polycarboxylate Cement 0
Polyurethanes 0
Silicones 0
polycarbonate 25766-59-0
baysilon 63148-62-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1109-1120

Informations de copyright

© 2022 Wiley Periodicals LLC.

Références

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Auteurs

Tamer Al Kayal (T)

Institute of Clinical Physiology, National Research Council, Massa, Italy.

Paola Losi (P)

Institute of Clinical Physiology, National Research Council, Massa, Italy.

Marianna Asaro (M)

Institute of Clinical Physiology, National Research Council, Massa, Italy.

Silvia Volpi (S)

Institute of Clinical Physiology, National Research Council, Massa, Italy.

Walter Bonani (W)

European Commission, Joint Research Centre, Karlsruhe, Germany.

Massimo Bonini (M)

Department of Chemistry "Ugo Schiff" and CSGI, University of Florence, Sesto Fiorentino, Italy.

Giorgio Soldani (G)

Institute of Clinical Physiology, National Research Council, Massa, Italy.

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