SARS-CoV-2 Omicron virus causes attenuated disease in mice and hamsters.

Angiotensin-Converting Enzyme 2 / genetics Animals COVID-19 / pathology Cricetinae Disease Models, Animal Female Humans Lung / pathology Male Mesocricetus Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Transgenic SARS-CoV-2 / pathogenicity Viral Load

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
03 2022
Historique:
received: 28 12 2021
accepted: 19 01 2022
pubmed: 22 1 2022
medline: 1 4 2022
entrez: 21 1 2022
Statut: ppublish

Résumé

The recent emergence of B.1.1.529, the Omicron variant

Identifiants

DOI: 10.1038/s41586-022-04441-6 PMID: 35062015 PMC: PMC8942849
pubmed: 35062015
doi: 10.1038/s41586-022-04441-6
pii: 10.1038/s41586-022-04441-6
pmc: PMC8942849
doi:

Substances chimiques

ACE2 protein, human EC 3.4.17.23
Angiotensin-Converting Enzyme 2 EC 3.4.17.23

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

687-692

Subventions

Organisme : NIAID NIH HHS
ID : T32 AI007647
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : P51OD011132
Organisme : NIAID NIH HHS
ID : HHSN272201400008C
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00017
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI151810
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00016
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK130425
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129269
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI060699
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201400004C
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93021C00014
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI147623
Pays : United States
Organisme : NIAID NIH HHS
ID : 75N93019C00051
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : R56AI147623
Organisme : NIH HHS
ID : P51 OD011132
Pays : United States
Organisme : NIAID NIH HHS
ID : HHSN272201700041I
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI157155
Pays : United States
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases)
ID : R01DK130425
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : 75N93020F00001/A38
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID)
ID : R01 AI129269

Investigateurs

B Alburquerque (B)
H Alshammary (H)
A A Amoako (AA)
S Aslam (S)
R Banu (R)
C Cognigni (C)
M Espinoza-Moraga (M)
K Farrugia (K)
A van de Guchte (A)
Z Khalil (Z)
M Laporte (M)
I Mena (I)
A E Paniz-Mondolfi (AE)
J Polanco (J)
A Rooker (A)
L A Sominsky (LA)

Commentaires et corrections

Type : UpdateOf

Informations de copyright

© 2022. The Author(s).

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Auteurs

Peter J Halfmann (PJ)

Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Shun Iida (S)

Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
ORCID: 0000-0003-2258-9031

Kiyoko Iwatsuki-Horimoto (K)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
ORCID: 0000-0002-8266-020X

Tadashi Maemura (T)

Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Maki Kiso (M)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Suzanne M Scheaffer (SM)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

Tamarand L Darling (TL)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

Astha Joshi (A)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0003-4914-8228

Samantha Loeber (S)

Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Gagandeep Singh (G)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-3260-2631

Stephanie L Foster (SL)

Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
ORCID: 0000-0002-3097-1129

Baoling Ying (B)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

James Brett Case (JB)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0001-7331-5511

Zhenlu Chong (Z)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

Bradley Whitener (B)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0001-6652-0701

Juan Moliva (J)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Katharine Floyd (K)

Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
ORCID: 0000-0002-0866-6961

Michiko Ujie (M)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Noriko Nakajima (N)

Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.

Mutsumi Ito (M)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Ryan Wright (R)

Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA.

Ryuta Uraki (R)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
ORCID: 0000-0003-0890-1922

Prajakta Warang (P)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Matthew Gagne (M)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Rong Li (R)

Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA.

Yuko Sakai-Tagawa (Y)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Yanan Liu (Y)

Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA.

Deanna Larson (D)

Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA.

Jorge E Osorio (JE)

Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
Colombia/Wisconsin One-Health Consortium and One-Health Genomic Laboratory, Universidad Nacional de Colombia, Medellín, Colombia.

Juan P Hernandez-Ortiz (JP)

Colombia/Wisconsin One-Health Consortium and One-Health Genomic Laboratory, Universidad Nacional de Colombia, Medellín, Colombia.
ORCID: 0000-0003-0404-9947

Amy R Henry (AR)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Karl Ciuoderis (K)

Colombia/Wisconsin One-Health Consortium and One-Health Genomic Laboratory, Universidad Nacional de Colombia, Medellín, Colombia.

Kelsey R Florek (KR)

Wisconsin State Laboratory of Hygiene, Madison, WI, USA.
ORCID: 0000-0002-8743-8579

Mit Patel (M)

Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.

Abby Odle (A)

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.

Lok-Yin Roy Wong (LR)

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.

Allen C Bateman (AC)

Wisconsin State Laboratory of Hygiene, Madison, WI, USA.

Zhongde Wang (Z)

Department of Animal Dairy, and Veterinary Sciences, College of Agriculture and Applied Sciences, Utah State University, Logan, UT, USA.
ORCID: 0000-0003-2441-4729

Venkata-Viswanadh Edara (VV)

Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
ORCID: 0000-0001-9321-7839

Zhenlu Chong (Z)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.

John Franks (J)

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Trushar Jeevan (T)

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Thomas Fabrizio (T)

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
ORCID: 0000-0002-8960-0728

Jennifer DeBeauchamp (J)

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Lisa Kercher (L)

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Patrick Seiler (P)

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.

Ana Silvia Gonzalez-Reiche (AS)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-3583-4497

Emilia Mia Sordillo (EM)

Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0001-7787-3051

Lauren A Chang (LA)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-3287-3987

Harm van Bakel (H)

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-1376-6916

Viviana Simon (V)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-6416-5096

Daniel C Douek (DC)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Nancy J Sullivan (NJ)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.

Larissa B Thackray (LB)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0002-9380-6569

Hiroshi Ueki (H)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
ORCID: 0000-0002-6557-0771

Seiya Yamayoshi (S)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
ORCID: 0000-0001-7768-5157

Masaki Imai (M)

Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
ORCID: 0000-0001-6988-1975

Stanley Perlman (S)

Department of Microbiology and Immunology, University of Iowa, Iowa City, IA, USA.
ORCID: 0000-0003-4213-2354

Richard J Webby (RJ)

Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee, USA.
ORCID: 0000-0002-4397-7132

Robert A Seder (RA)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
ORCID: 0000-0003-3133-0849

Mehul S Suthar (MS)

Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA.

Adolfo García-Sastre (A)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0002-6551-1827

Michael Schotsaert (M)

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
ORCID: 0000-0003-3156-3132

Tadaki Suzuki (T)

Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan.
ORCID: 0000-0002-3820-9542

Adrianus C M Boon (ACM)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. jboon@wustl.edu.
Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. jboon@wustl.edu.
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. jboon@wustl.edu.
ORCID: 0000-0002-4700-8224

Michael S Diamond (MS)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.
Department of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.
The Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St Louis, MO, USA. mdiamond@wustl.edu.
ORCID: 0000-0002-8791-3165

Yoshihiro Kawaoka (Y)

Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA. yoshihiro.kawaoka@wisc.edu.
Division of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.
The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, Japan. yoshihiro.kawaoka@wisc.edu.
ORCID: 0000-0001-5061-8296

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Exopeptidases › Carboxypeptidases › Angiotensin-converting enzyme 2 › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Appareil respiratoire › Poumon › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Arvicolinae › Cricetinae › Mesocricetus › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › SARS-CoV-2 Omicron virus causes attenuated...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › SARS-CoV-2 Omicron virus causes attenuated...