Rapid Weight Loss, Central Obesity Improvement and Blood Glucose Reduction Are Associated with a Stronger Adaptive Immune Response Following COVID-19 mRNA Vaccine.
BMI
SARS CoV-2
diabetes
immunogenicity
infection
vaccination
waist circumference
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
05 Jan 2022
05 Jan 2022
Historique:
received:
17
12
2021
revised:
28
12
2021
accepted:
04
01
2022
entrez:
22
1
2022
pubmed:
23
1
2022
medline:
23
1
2022
Statut:
epublish
Résumé
Obesity is associated with a poor COVID-19 prognosis, and it seems associated with reduced humoral response to vaccination. Public health campaigns have advocated for weight loss in subjects with obesity, hoping to eliminate this risk. However, no evidence proves that weight loss leads to a better prognosis or a stronger immune response to vaccination. We aimed to investigate the impact of rapid weight loss on the adaptive immune response in subjects with morbid obesity. Twenty-one patients followed a hypocaloric, very-low-carbohydrate diet one week before to one week after the two mRNA vaccine doses. The diet's safety and efficacy were assessed, and the adaptive humoral (anti-SARS CoV-2 S antibodies, Abs) and cell-mediated responses (IFNγ secretion on stimulation with two different SARS CoV-2 peptide mixes, IFNγ-1 and IFNγ-2) were evaluated. The patients lost ~10% of their body weight with metabolic improvement. A high baseline BMI correlated with a poor immune response (R -0.558,
Identifiants
pubmed: 35062740
pii: vaccines10010079
doi: 10.3390/vaccines10010079
pmc: PMC8780354
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ministry of Education, Universities and Research
ID : Prot.2017L8Z2E
Organisme : Ministry of Education, Universities and Research
ID : Prot. 2020NCKXBR
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