Immunoprofiling Identifies Functional B and T Cell Subsets Induced by an Attenuated Whole Parasite Malaria Vaccine as Correlates of Sterile Immunity.

correlate of protection immune signature machine learning malaria whole sporozoites vaccine

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
14 Jan 2022
Historique:
received: 15 12 2021
revised: 06 01 2022
accepted: 11 01 2022
entrez: 22 1 2022
pubmed: 23 1 2022
medline: 23 1 2022
Statut: epublish

Résumé

Immune correlates of protection remain elusive for most vaccines. An identified immune correlate would accelerate the down-selection of vaccine formulations by reducing the need for human pathogen challenge studies that are currently required to determine vaccine efficacy. Immunization via mosquito-delivered, radiation-attenuated

Identifiants

pubmed: 35062785
pii: vaccines10010124
doi: 10.3390/vaccines10010124
pmc: PMC8780163
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Military Infectious Disease Research Program
ID : (F0570_19_WR)

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Auteurs

Marie Mura (M)

Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Immunopathology, Institut de Recherche Biomédicale des Armées, 91223 CEDEX, BP73 Brétigny-sur-Orge, France.

Pinyi Lu (P)

Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, U.S. Army Medical Research and Development Command, Fort Detrick, MD 21702, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.

Tanmaya Atre (T)

Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Michael Cuccione Childhood Cancer Research Program, BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.

Jessica S Bolton (JS)

Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.
Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD 20817, USA.

Elizabeth H Duncan (EH)

Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Sidhartha Chaudhury (S)

Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Elke S Bergmann-Leitner (ES)

Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA.

Classifications MeSH