A tiered approach to investigate the inhalation toxicity of cobalt substances. Tier 2a: Grouping cobalt compounds based on their capacity to stabilize HIF-1α in human alveolar epithelial cells in vitro.
Cytotoxicity
Hypoxia
Lung
Metals
Solubility
Journal
Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983
Informations de publication
Date de publication:
Apr 2022
Apr 2022
Historique:
received:
18
10
2021
revised:
22
12
2021
accepted:
06
01
2022
pubmed:
23
1
2022
medline:
17
3
2022
entrez:
22
1
2022
Statut:
ppublish
Résumé
Excessive inhalation of cobalt (Co) dust can have harmful effects on the respiratory tract, yet all cobalt substances do not have the same potential for inducing toxicity. The prevalent hypothesis is that the potential of Co substances to release Co
Identifiants
pubmed: 35063568
pii: S0273-2300(22)00008-3
doi: 10.1016/j.yrtph.2022.105121
pii:
doi:
Substances chimiques
Endotoxins
0
Hypoxia-Inducible Factor 1, alpha Subunit
0
Cobalt
3G0H8C9362
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
105121Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.