Reproductive Factors Do Not Influence Survival with Ovarian Cancer.

Carcinoma, Ovarian Epithelial Female Humans Menarche Ovarian Neoplasms Parity Pregnancy Reproductive History Risk Factors

Journal

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608

Informations de publication

Date de publication:
01 04 2022
Historique:
received: 17 09 2021
revised: 23 11 2021
accepted: 18 01 2022
pubmed: 23 1 2022
medline: 6 4 2022
entrez: 22 1 2022
Statut: ppublish

Résumé

Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes. Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype. During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype. This study found no association between reproductive factors and survival after an ovarian cancer diagnosis. Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.

Sections du résumé

BACKGROUND
Previous studies on the association between reproductive factors and ovarian cancer survival are equivocal, possibly due to small sample sizes.
METHODS
Using data on 11,175 people diagnosed with primary invasive epithelial ovarian, fallopian tube, or primary peritoneal cancer (ovarian cancer) from 16 studies in the Ovarian Cancer Association Consortium (OCAC), we examined the associations between survival and age at menarche, combined oral contraceptive use, parity, breastfeeding, age at last pregnancy, and menopausal status using Cox proportional hazard models. The models were adjusted for age at diagnosis, race/ethnicity, education level, and OCAC study and stratified on stage and histotype.
RESULTS
During the mean follow-up of 6.34 years (SD = 4.80), 6,418 patients passed away (57.4%). There was no evidence of associations between the reproductive factors and survival among patients with ovarian cancer overall or by histotype.
CONCLUSIONS
This study found no association between reproductive factors and survival after an ovarian cancer diagnosis.
IMPACT
Reproductive factors are well-established risk factors for ovarian cancer, but they are not associated with survival after a diagnosis of ovarian cancer.

Identifiants

DOI: 10.1158/1055-9965.EPI-21-1091 PMID: 35064059 PMC: PMC9444326
pubmed: 35064059
pii: 1055-9965.EPI-21-1091
doi: 10.1158/1055-9965.EPI-21-1091
pmc: PMC9444326
mid: NIHMS1775076
doi:

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

909-913

Subventions

Organisme : NCI NIH HHS
ID : R01 CA136891
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA159981
Pays : United States
Organisme : Cancer Research UK
ID : C490/A8339
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C490/A16561
Pays : United Kingdom
Organisme : Cancer Research UK
ID : C490/A10124
Pays : United Kingdom
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States
Organisme : Cancer Research UK
ID : C490/A10119
Pays : United Kingdom

Informations de copyright

©2022 American Association for Cancer Research.

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Auteurs

Minh Tung Phung (MT)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.
ORCID: 0000-0002-3573-4501

Aliya Alimujiang (A)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.

Andrew Berchuck (A)

Division of Gynecologic Oncology, Duke University School of Medicine, Durham, North Carolina.

Hoda Anton-Culver (H)

Department of Medicine, University of California Irvine, Irvine, California.

Joellen M Schildkraut (JM)

Emory University Rollins School of Public Health, Atlanta, Georgia.

Elisa V Bandera (EV)

Cancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey.
ORCID: 0000-0002-8789-2755

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Cancer Epidemiology Group, University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-8919-1971

Anne Chase (A)

Patient Advocate.

Jennifer Anne Doherty (JA)

Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.
ORCID: 0000-0002-1454-8187

Bronwyn Grout (B)

Patient Advocate.

Marc T Goodman (MT)

Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.
Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Gillian E Hanley (GE)

Department of Obstetrics and Gynecology, University of British Columbia Faculty of Medicine, Vancouver, Canada.

Alice W Lee (AW)

Department of Public Health, California State University, Fullerton, Fullerton, California.
ORCID: 0000-0001-8756-7066

Cindy McKinnon Deurloo (C)

Patient Advocate.

Usha Menon (U)

MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, UCL, London, United Kingdom.
ORCID: 0000-0003-3708-1732

Francesmary Modugno (F)

Women's Cancer Research Center, Magee-Women's Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburg, Pennsylvania.
ORCID: 0000-0003-0637-1534

Paul D P Pharoah (PDP)

Department of Oncology, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
Department of Public Health and Primary Care, Center for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, United Kingdom.
ORCID: 0000-0001-8494-732X

Malcolm C Pike (MC)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York.
ORCID: 0000-0003-4891-1199

Jean Richardson (J)

Patient Advocate.
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
ORCID: 0000-0002-8273-6518

Harvey A Risch (HA)

Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.

Weiva Sieh (W)

Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
ORCID: 0000-0003-0085-1190

Kathryn L Terry (KL)

Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, Massachusetts.
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Penelope M Webb (PM)

Department of Population Health, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID: 0000-0003-0733-5930

Nicolas Wentzensen (N)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.

Anna H Wu (AH)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.

Celeste Leigh Pearce (CL)

Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.

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Classifications MeSH

questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Carcinome épithélial de l'ovaire › Reproductive Factors Do Not Influence Survival...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Reproductive Factors Do Not Influence Survival...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Développement sexuel › Puberté › Ménarche › Reproductive Factors Do Not Influence Survival...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › Reproductive Factors Do Not Influence Survival...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Antécédents gynécologiques et obstétricaux › Parité › Reproductive Factors Do Not Influence Survival...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Reproductive Factors Do Not Influence Survival...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Facteurs épidémiologiques › Antécédents gynécologiques et obstétricaux › Reproductive Factors Do Not Influence Survival...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Reproductive Factors Do Not Influence Survival...