Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT.
Ayahuasca
Deuterhuasca
Dimethyltryptamine
Monoamine oxidase inhibitor
Pharmahuasca
Psychedelic therapeutics
Sigma-1 receptor
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
12
08
2021
accepted:
11
01
2022
pubmed:
23
1
2022
medline:
9
6
2022
entrez:
22
1
2022
Statut:
ppublish
Résumé
As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic. This review will focus on these factors as they relate to the psychedelic N,N-dimethyltryptamine (DMT). It will examine the positive and negative aspects of different formulations and routes of administration of DMT and the observed effects from such administrations in the form of ayahuasca teas; oral "pharmahuasca"; injections by intravenous (IV) and intramuscular (IM) routes; inhalation, insufflation; and other routes; and high-dose, low-dose, and "micro-dose" effects. The review will consider possible oral route of administration alternatives that would not require concomitant use of a monoamine oxidase inhibitor. The review will then address the current research findings for DMT from in vivo and in vitro studies as well as the possibility that these findings may be revealing the role of endogenous DMT in normal brain function.
Identifiants
pubmed: 35064294
doi: 10.1007/s00213-022-06065-0
pii: 10.1007/s00213-022-06065-0
pmc: PMC8782705
doi:
Substances chimiques
Hallucinogens
0
Monoamine Oxidase Inhibitors
0
N,N-Dimethyltryptamine
WUB601BHAA
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1749-1763Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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