Improved solubility of lornoxicam by inclusion into SBA-15: Comparison of loading methods.
Dissolution rate
Drug delivery system
Lornoxicam
Mesoporous silica
Physicochemical techniques
SBA-15
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
01 Apr 2022
01 Apr 2022
Historique:
received:
21
08
2021
revised:
09
11
2021
accepted:
19
01
2022
pubmed:
24
1
2022
medline:
24
2
2022
entrez:
23
1
2022
Statut:
ppublish
Résumé
An increasing proportion of new medicinal substances are poorly soluble in water. Adsorption on mesoporous silicas increases their bioavailability when administered orally. Loading method determines adsorption either on the surface in crystalline state or inside the mesopores in amorphus form. The aim of this study was to compare two methods (adsorption equilibrium and solvent evaporation) of lornoxicam adsorption on SBA-15 and APTES-modified SBA-15 in terms of drug adsorption site. Additionally, we investigated the drug release profiles at different pH and cytotoxicity of the analysed mesoporous materials. The materials were characterized by a number of physicochemical techniques including X-ray diffraction, nitrogen adsorption/desorption techniques, differential scanning calorimetry, thermogravimetric analysis, scanning and transmission electron microscopy, infrared spectroscopy and
Identifiants
pubmed: 35066153
pii: S0928-0987(22)00018-5
doi: 10.1016/j.ejps.2022.106133
pii:
doi:
Substances chimiques
Drug Carriers
0
SBA-15
0
Piroxicam
13T4O6VMAM
Silicon Dioxide
7631-86-9
lornoxicam
ER09126G7A
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
106133Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.