Study of the neurochemical alterations produced by acute and subchronic Pb-exposure in Meriones shawi: Immunohistochemical study of Reissner's fiber secretion by the subcommissural organ after curcumin-III treatment.
Curcumin-III
Lead
Meriones shawi
Reissner’s fiber
Subcommissural organ
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
14
06
2021
revised:
13
12
2021
accepted:
14
01
2022
medline:
23
10
2023
pubmed:
24
1
2022
entrez:
23
1
2022
Statut:
ppublish
Résumé
Lead neurotoxicity is associated with numerous alterations including behavioral and neurochemical disruptions. This study evaluates the possible neurochemical disruption in the subcommissural organ (SCO) after acute (three days) and subchronic (six weeks) Pb-exposure inMeriones shawi, and the possible effect of the third active compound, curcumin-III, in mitigating the neurological alterations caused by lead exposure. Using immunohistochemical stainings, we evaluated the Reissner's fiber (RF) secretion utilizing RF-antibody in the SCO. We compared both acute (25 mg/kg bw of Pb i.p. for 3 days) and subchronic (3 g/l of Pb in drinking water for six weeks) Pb-treatedMeriones shawi. The two models of lead exposure showed a significant increase in RF level in the SCO. Conversely, co-treatment with Curcumin-III at a dose of 30 mg/kg bw significantly ameliorate SCO secretory activity, as revealed by decreased RF-immunoreactivity. Together, our findings suggest the protective effects of Curcumin-III in regulating the secretory activity of the SCO after Pb-induced neuroanatomical disruptions of the SCO in Meriones.
Sections du résumé
BACKGROUND
BACKGROUND
Lead neurotoxicity is associated with numerous alterations including behavioral and neurochemical disruptions. This study evaluates the possible neurochemical disruption in the subcommissural organ (SCO) after acute (three days) and subchronic (six weeks) Pb-exposure inMeriones shawi, and the possible effect of the third active compound, curcumin-III, in mitigating the neurological alterations caused by lead exposure.
METHODS
METHODS
Using immunohistochemical stainings, we evaluated the Reissner's fiber (RF) secretion utilizing RF-antibody in the SCO. We compared both acute (25 mg/kg bw of Pb i.p. for 3 days) and subchronic (3 g/l of Pb in drinking water for six weeks) Pb-treatedMeriones shawi.
RESULTS
RESULTS
The two models of lead exposure showed a significant increase in RF level in the SCO. Conversely, co-treatment with Curcumin-III at a dose of 30 mg/kg bw significantly ameliorate SCO secretory activity, as revealed by decreased RF-immunoreactivity.
CONCLUSION
CONCLUSIONS
Together, our findings suggest the protective effects of Curcumin-III in regulating the secretory activity of the SCO after Pb-induced neuroanatomical disruptions of the SCO in Meriones.
Identifiants
pubmed: 35066456
pii: S0946-672X(22)00013-X
doi: 10.1016/j.jtemb.2022.126933
pii:
doi:
Substances chimiques
Lead
2P299V784P
curcumin III
33171-05-0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
126933Informations de copyright
Copyright © 2022. Published by Elsevier GmbH.