The Fate of Erythrocytes after Cerebral Hemorrhage.

Brain Injuries / metabolism Cerebral Hemorrhage / complications Erythrocytes / metabolism Hemolysis Humans Microglia Neurotoxins / metabolism
Cerebral hemorrhage Complement Erythrocytes Erythrolysis Macrophages Microglia Phagocytosis

Journal

Translational stroke research
ISSN: 1868-601X
Titre abrégé: Transl Stroke Res
Pays: United States
ID NLM: 101517297

Informations de publication

Date de publication:
10 2022
Historique:
received: 15 11 2021
accepted: 16 12 2021
revised: 16 12 2021
pubmed: 24 1 2022
medline: 24 8 2022
entrez: 23 1 2022
Statut: ppublish

Résumé

After a cerebral hemorrhage (intracerebral, subarachnoid, and intraventricular), extravasated blood contributes to both initial brain injury, via physical disruption and mass effect, and secondary injury, through the release of potentially neurotoxic and pro-inflammatory factors such as hemoglobin, iron, and peroxiredoxin-2. Erythrocytes are a major blood component and are a source of such damaging factors. Erythrolysis after cerebral hemorrhage releases potential neurotoxins, contributing to brain injury and edema. Alternatively, erythrocyte phagocytosis via microglia or macrophages may limit the spill of neurotoxins therefore limiting subsequent brain injury. The aim of this review is to discuss the process of phagocytosis of erythrocytes by microglia or macrophages after cerebral hemorrhage, the effect of erythrolysis on brain injury, novel mechanisms of erythrocyte and phagocyte egress from the brain, and exciting new targets in this pathway to attenuate brain injury. Understanding the fate of erythrocytes after cerebral hemorrhage may uncover additional potential interventions for clinical translational research.

Identifiants

DOI: 10.1007/s12975-021-00980-8 PMID: 35066815 PMC: PMC9782724
pubmed: 35066815
doi: 10.1007/s12975-021-00980-8
pii: 10.1007/s12975-021-00980-8
pmc: PMC9782724
mid: NIHMS1856115
doi:

Substances chimiques

Neurotoxins 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

655-664

Subventions

Organisme : NINDS NIH HHS
ID : NS116786
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS096917
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106746
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS112394
Pays : United States
Organisme : NINDS NIH HHS
ID : R35 NS116786
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Références

Stroke. 2021 Aug;52(8):2649-2660
pubmed: 34176310
Exp Neurol. 2021 Jun;340:113654
pubmed: 33617886
Blood. 2011 Jul 21;118(3):712-22
pubmed: 21555741
Stroke. 2009 Jun;40(6):2241-3
pubmed: 19372448
Cell Mol Life Sci. 2021 Mar;78(6):2429-2457
pubmed: 33427948
J Immunol. 2014 Jun 15;192(12):5984-92
pubmed: 24808360
Transl Stroke Res. 2021 Jun;12(3):496-511
pubmed: 32989665
Lancet. 2013 Aug 3;382(9890):397-408
pubmed: 23726393
J Cereb Blood Flow Metab. 2019 Mar;39(3):562-564
pubmed: 30540218
Nat Med. 2012 Jun;18(6):911-7
pubmed: 22610280
Nat Commun. 2020 Jun 22;11(1):3159
pubmed: 32572022
Stroke. 2003 Dec;34(12):2964-9
pubmed: 14615611
mBio. 2014 Aug 26;5(5):e01251-14
pubmed: 25161188
Ann Neurol. 2007 Apr;61(4):352-62
pubmed: 17457822
N Engl J Med. 2013 Jun 20;368(25):2355-65
pubmed: 23713578
Biomolecules. 2021 Apr 29;11(5):
pubmed: 33946699
Neurosurgery. 1996 Jul;39(1):141-5; discussion 145-6
pubmed: 8805150
Acta Neurochir Suppl. 2011;111:71-5
pubmed: 21725734
Stroke. 2018 Feb;49(2):275-276
pubmed: 29301975
Int J Biochem Cell Biol. 2012 Aug;44(8):1236-43
pubmed: 22561748
Lancet. 2017 Feb 11;389(10069):603-611
pubmed: 28081952
FEBS J. 2019 Mar;286(5):826-854
pubmed: 30028073
Cerebrospinal Fluid Res. 2004 Dec 10;1(1):2
pubmed: 15679948
Oxid Med Cell Longev. 2019 Nov 11;2019:9613090
pubmed: 31827713
J Cereb Blood Flow Metab. 2014 Jun;34(6):1070-5
pubmed: 24667910
J Membr Biol. 1983;75(3):225-31
pubmed: 6631943
Stroke. 2016 Feb;47(2):505-11
pubmed: 26732568
Nat Immunol. 2011 Jun 26;12(8):761-9
pubmed: 21706006
J Neurosurg. 2002 Feb;96(2):287-93
pubmed: 11838803
J Cereb Blood Flow Metab. 2003 Jun;23(6):629-52
pubmed: 12796711
Neurobiol Dis. 2021 Jul;155:105384
pubmed: 33945877
J Immunol. 1992 May 15;148(10):3210-5
pubmed: 1578145
Transl Stroke Res. 2010 Mar 1;1(1):31-4
pubmed: 20811505
Sci Transl Med. 2012 Aug 15;4(147):147ra111
pubmed: 22896675
Stroke. 2019 Jun;50(6):1539-1547
pubmed: 31084334
No Shinkei Geka. 2005 Dec;33(12):1177-81
pubmed: 16359028
J Cereb Blood Flow Metab. 2006 Dec;26(12):1490-5
pubmed: 16552422
Transl Stroke Res. 2020 Jun;11(3):541-551
pubmed: 31664629
Transl Stroke Res. 2013 Oct;4(5):546-53
pubmed: 24187595
J Proteome Res. 2017 Aug 4;16(8):2752-2761
pubmed: 28689405
Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32679-32690
pubmed: 33293423
Stroke. 2020 May;51(5):1578-1586
pubmed: 32279622
Elife. 2019 May 07;8:
pubmed: 31063132
Prog Neurobiol. 2014 Apr;115:45-63
pubmed: 24139872
Lancet. 2019 Aug 24;394(10199):e20
pubmed: 31448742
Stroke. 2009 Mar;40(3 Suppl):S92-4
pubmed: 19064796
Transl Stroke Res. 2017 Apr;8(2):174-182
pubmed: 27783383
J Cereb Blood Flow Metab. 2021 Aug;41(8):1842-1857
pubmed: 33444089
Neurobiol Dis. 2019 Jun;126:76-84
pubmed: 29879529
Nat Med. 2016 Aug;22(8):945-51
pubmed: 27428900
CNS Neurosci Ther. 2021 Oct;27(10):1118-1126
pubmed: 34145764
Stroke. 2019 Jul;50(7):1859-1868
pubmed: 31177985
Stroke. 2020 Feb;51(2):612-618
pubmed: 31826730
Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):
pubmed: 33446503
Stroke. 2001 Jan;32(1):162-7
pubmed: 11136932
J Neurochem. 2015 Apr;133(1):144-52
pubmed: 25328080
J Leukoc Biol. 2006 Dec;80(6):1281-8
pubmed: 16963624
CNS Neurosci Ther. 2020 Sep;26(9):896-901
pubmed: 32436273
Biomolecules. 2021 Jun 18;11(6):
pubmed: 34207338
Stroke. 2021 May;52(5):1798-1808
pubmed: 33840225
Nat Commun. 2017 Nov 10;8(1):1434
pubmed: 29127332
Stroke. 2016 Jun;47(6):1626-31
pubmed: 27125525
Transl Stroke Res. 2021 Oct;12(5):858-865
pubmed: 33094829
J Neurosurg. 2000 Jun;92(6):1016-22
pubmed: 10839264
Sci Adv. 2021 Oct 29;7(44):eabh0050
pubmed: 34705495
Br Med Bull. 2000;56(2):444-56
pubmed: 11092093
N Engl J Med. 2016 Sep 15;375(11):1033-43
pubmed: 27276234
Transl Stroke Res. 2020 Oct;11(5):1095-1102
pubmed: 32090277
Cells. 2019 Jan 27;8(2):
pubmed: 30691235
Transl Stroke Res. 2019 Feb;10(1):52-56
pubmed: 29766451
J Neurosurg. 1998 Dec;89(6):991-6
pubmed: 9833826
Lancet. 2019 Mar 9;393(10175):1021-1032
pubmed: 30739747
Transl Stroke Res. 2020 Apr;11(2):288-295
pubmed: 31273681
Fluids Barriers CNS. 2021 Aug 16;18(1):38
pubmed: 34399800
Transl Stroke Res. 2012 Mar;3(1):130-7
pubmed: 22400066
J Cereb Blood Flow Metab. 2018 Apr;38(4):741-745
pubmed: 29350086

Auteurs

Fan Xia (F)

Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.

Richard F Keep (RF)

Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

Fenghui Ye (F)

Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

Katherine G Holste (KG)

Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

Shu Wan (S)

Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA.

Guohua Xi (G)

Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA. guohuaxi@umich.edu.
ORCID: 0000-0003-2846-5937

Ya Hua (Y)

Department of Neurosurgery, University of Michigan, 5018 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200, USA. yahua@umich.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › The Fate of Erythrocytes after Cerebral Hemorrhage.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Hémorragie › Hémorragies intracrâniennes › Hémorragie cérébrale › The Fate of Erythrocytes after Cerebral Hemorrhage.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Sang › Cellules sanguines › Érythrocytes › The Fate of Erythrocytes after Cerebral Hemorrhage.
questionsmedicales.fr › Phénomènes du système immunitaire › Réaction antigène-anticorps › Hémolyse › The Fate of Erythrocytes after Cerebral Hemorrhage.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Fate of Erythrocytes after Cerebral Hemorrhage.
questionsmedicales.fr › Cellules › Névroglie › Microglie › The Fate of Erythrocytes after Cerebral Hemorrhage.
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Neurotoxines › The Fate of Erythrocytes after Cerebral Hemorrhage.