Oblique saccades in internuclear ophthalmoplegia.

Cross-Sectional Studies Humans Multiple Sclerosis / complications Ocular Motility Disorders / etiology Saccades
Adaptation Component stretching Curvature Internuclear ophthalmoplegia Multiple sclerosis Saccadic control

Journal

Experimental brain research
ISSN: 1432-1106
Titre abrégé: Exp Brain Res
Pays: Germany
ID NLM: 0043312

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 29 05 2021
accepted: 30 11 2021
pubmed: 25 1 2022
medline: 16 3 2022
entrez: 24 1 2022
Statut: ppublish

Résumé

Oblique saccades often display component stretching, in which the shorter vector in one cardinal direction is slowed so that its duration matches that of the longer vector in the orthogonal direction, resulting in a straighter trajectory. In internuclear ophthalmoplegia, adducting saccades are typically slowed while vertical saccades are unaffected. It is not known whether these slowed adducting movements are accompanied by adaptive component stretching of the vertical vector during oblique saccades. This was a cross-sectional study. We recorded the saccadic eye movement in 5 patients with right or bilateral internuclear ophthalmoplegia from multiple sclerosis and 17 healthy controls, using an EyeLink 1000 machine. The target stimulus was located at varying angles (0-360) and amplitudes (4, 8, 12 degrees). For each saccade we have calculated the curvature index as the main outcome measure, which is the area between the actual and ideal straight trajectory for oblique saccadic eye movements, divided by the square of the length of the straight trajectory, to give a unit-less metric for curvature. In the 17 control subjects, curvature showed a strong positive correlation between adducting saccades and the yoked abducting saccades of the other eye. In internuclear ophthalmoplegia, adducting saccades showed a strong curvature concave to the horizontal meridian, indicating inadequate component stretching, while abducting saccades did not differ from controls. This new sign of oblique saccadic curvature in internuclear ophthalmoplegia indicates a limitation of the range of central adaptive changes in response to distal lesions affecting transmission of the saccadic command.

Identifiants

DOI: 10.1007/s00221-021-06283-6 PMID: 35067725
pubmed: 35067725
doi: 10.1007/s00221-021-06283-6
pii: 10.1007/s00221-021-06283-6
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

861-869

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

Oded Rock (O)

Human Vision and Eye Movement (HVEM) Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada. odedrock@gmail.com.
ORCID: 0000-0002-6883-7398

Andrea Albonico (A)

Human Vision and Eye Movement (HVEM) Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada.

Farnaz Javadian (F)

Human Vision and Eye Movement (HVEM) Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada.

Mohammad Ashkanani (M)

Human Vision and Eye Movement (HVEM) Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada.
Department of Medicine, Division of Neurology and Epilepsy, Amiri Hospital, Kuwait City, Kuwait.

Alisdair J G Taylor (AJG)

Human Vision and Eye Movement (HVEM) Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada.

Michael Dreyer (M)

Department of Neurology, University of Tasmania, Hobart, TAS, Australia.

Jason J S Barton (JJS)

Human Vision and Eye Movement (HVEM) Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, 2550 Willow Street, Vancouver, BC, V5Z 3N9, Canada.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Oblique saccades in internuclear ophthalmoplegia.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Oblique saccades in internuclear ophthalmoplegia.
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Oblique saccades in internuclear ophthalmoplegia.
questionsmedicales.fr › Maladies de l'oeil › Troubles de la motilité oculaire › Oblique saccades in internuclear ophthalmoplegia.
questionsmedicales.fr › Phénomènes physiologiques oculaires › Mouvements oculaires › Saccades › Oblique saccades in internuclear ophthalmoplegia.