Clinical endpoints of needle-free jet injector treatment: An in depth understanding of immediate skin responses.
dermatology
drug delivery
injection
intralesional
jet injection
needle-free injection
pneumatic injection
Journal
Lasers in surgery and medicine
ISSN: 1096-9101
Titre abrégé: Lasers Surg Med
Pays: United States
ID NLM: 8007168
Informations de publication
Date de publication:
07 2022
07 2022
Historique:
revised:
27
12
2021
received:
12
08
2021
accepted:
10
01
2022
pubmed:
25
1
2022
medline:
14
6
2022
entrez:
24
1
2022
Statut:
ppublish
Résumé
Needle-free jet injectors have been used in dermatological practice for many years. However, predefined clinical endpoints that guide physicians to choose optimal device settings have not been clearly defined. Here, we evaluate immediate skin responses as clinical endpoints for needle-free jet injector treatments. We injected methylene blue in ex vivo human skin using an electronically-controllable pneumatic injector (EPI; 3-6 bar, 50-130 µl; n = 63), and a spring-loaded jet injector (SLI) with fixed settings (100 µl; n = 9). We measured the immediate skin papule (3D-camera), residual surface fluid (pipette), dermal dye distribution by estimating depth and width, and subcutaneous dye deposition. EPI with 4 bar and 100 µl resulted in the largest skin papule of 48.7 mm The immediate skin papule and residual surface fluid correspond with dermal drug deposition and are relevant clinical endpoints for needle-free jet injector treatments in dermatological practice.
Identifiants
pubmed: 35067934
doi: 10.1002/lsm.23521
pmc: PMC9303610
doi:
Substances chimiques
Methylene Blue
T42P99266K
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
693-701Informations de copyright
© 2022 The Authors. Lasers in Surgery and Medicine published by Wiley Periodicals LLC.
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