ROS-Sensitive Polymer Micelles for Selective Degradation in Primary Human Monocytes from Patients with Active IBD.


Journal

Macromolecular bioscience
ISSN: 1616-5195
Titre abrégé: Macromol Biosci
Pays: Germany
ID NLM: 101135941

Informations de publication

Date de publication:
04 2022
Historique:
revised: 07 01 2022
received: 29 11 2021
pubmed: 25 1 2022
medline: 19 4 2022
entrez: 24 1 2022
Statut: ppublish

Résumé

Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas of the gastrointestinal tract and in circulating immune cells, providing novel opportunities for targeted drug delivery. In the recent experiments, oxidation-responsive polymeric nanostructures selectively degrade in the presence of H

Identifiants

pubmed: 35068059
doi: 10.1002/mabi.202100482
doi:

Substances chimiques

Micelles 0
Polymers 0
Reactive Oxygen Species 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2100482

Informations de copyright

© 2022 The Authors. Macromolecular Bioscience published by Wiley-VCH GmbH.

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Auteurs

Elena Gardey (E)

Department of Internal Medicine IV (Gastroenterology, Hepatology, Infectious Diseases and Interdisciplinary Endoscopy), Jena University Hospital, Am Klinikum 1, Jena, 07747, Germany.
Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena, 07743, Germany.

Fabian H Sobotta (FH)

Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena, 07743, Germany.
Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, Jena, 07743, Germany.

Stefanie Quickert (S)

Department of Internal Medicine IV (Gastroenterology, Hepatology, Infectious Diseases and Interdisciplinary Endoscopy), Jena University Hospital, Am Klinikum 1, Jena, 07747, Germany.

Tony Bruns (T)

Department of Medicine III, University Hospital RWTH Aachen, Pauwelsstraße 30, Aachen, 52074, Germany.

Johannes C Brendel (JC)

Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena, 07743, Germany.
Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstraße 10, Jena, 07743, Germany.

Andreas Stallmach (A)

Department of Internal Medicine IV (Gastroenterology, Hepatology, Infectious Diseases and Interdisciplinary Endoscopy), Jena University Hospital, Am Klinikum 1, Jena, 07747, Germany.
Jena Center for Soft Matter (JCSM), Friedrich Schiller University Jena, Philosophenweg 7, Jena, 07743, Germany.

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