Baseline predictors of progression of Parkinson's disease in a sample of Egyptian patients: clinical and biochemical.
COVID-19
Egyptian
Parkinson’s disease
Predictors
Progression
Journal
The Egyptian journal of neurology, psychiatry and neurosurgery
ISSN: 1110-1083
Titre abrégé: Egypt J Neurol Psychiatr Neurosurg
Pays: England
ID NLM: 0043617
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
11
2021
accepted:
01
01
2022
entrez:
24
1
2022
pubmed:
25
1
2022
medline:
25
1
2022
Statut:
ppublish
Résumé
Clinical progression of Parkinson's disease (PD) is highly heterogeneous, and its predictors are generally lacking. Identifying predictors of early disease progression is important for patients' management and follow-up. The current study aims to identify clinical, neuroimaging and biochemical baseline predictors of motor progression in patients with PD. Forty-five PD patients were assessed at baseline, 6 months and 1 year using MDS-UPDRS total and subscores, Hoehn and Yahr (H&Y), Schwab and England (S&E), International Physical Activity Questionnaire (IPAQ). Baseline New Freezing of Gait Questionnaire (NFOG-Q), Berg Balance Scale (BBS), Ten-Meter Walking Test (10-MWT) Significant worsening of MDS-UPDRS total, part III scores, H&Y, S&E and IPAQ ( Despite the significant motor and physical activity progression over 1 year that was correlated to baseline motor and gait severity, but without predictive value, further similar and longitudinal studies are warranted to detect predictors of early progression and confirm findings. The online version contains supplementary material available at 10.1186/s41983-022-00445-1.
Sections du résumé
BACKGROUND
BACKGROUND
Clinical progression of Parkinson's disease (PD) is highly heterogeneous, and its predictors are generally lacking. Identifying predictors of early disease progression is important for patients' management and follow-up. The current study aims to identify clinical, neuroimaging and biochemical baseline predictors of motor progression in patients with PD. Forty-five PD patients were assessed at baseline, 6 months and 1 year using MDS-UPDRS total and subscores, Hoehn and Yahr (H&Y), Schwab and England (S&E), International Physical Activity Questionnaire (IPAQ). Baseline New Freezing of Gait Questionnaire (NFOG-Q), Berg Balance Scale (BBS), Ten-Meter Walking Test (10-MWT)
RESULTS
RESULTS
Significant worsening of MDS-UPDRS total, part III scores, H&Y, S&E and IPAQ (
CONCLUSION
CONCLUSIONS
Despite the significant motor and physical activity progression over 1 year that was correlated to baseline motor and gait severity, but without predictive value, further similar and longitudinal studies are warranted to detect predictors of early progression and confirm findings.
SUPPLEMENTARY INFORMATION
BACKGROUND
The online version contains supplementary material available at 10.1186/s41983-022-00445-1.
Identifiants
pubmed: 35068922
doi: 10.1186/s41983-022-00445-1
pii: 445
pmc: PMC8760567
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
Competing interestsAll authors declare that they do not have any competing interests.
Références
Mov Disord. 2020 Jul;35(7):1097-1099
pubmed: 32428342
Eur J Clin Pharmacol. 2008 Feb;64(2):207-16
pubmed: 18092155
Parkinsonism Relat Disord. 2000 Apr 1;6(2):69-76
pubmed: 10699387
Proc IEEE Int Conf Acoust Speech Signal Process. 2020 May;2020:1319-1323
pubmed: 33708010
Lipids Health Dis. 2020 May 19;19(1):97
pubmed: 32430016
Ann Indian Acad Neurol. 2021 Mar-Apr;24(2):217-226
pubmed: 34220066
Phys Ther. 1999 Dec;79(12):1122-33
pubmed: 10630281
PLoS One. 2018 Jan 5;13(1):e0187939
pubmed: 29304183
Mov Disord. 2007 May 15;22(7):938-45
pubmed: 17415791
Mov Disord. 2009 Apr 15;24(5):655-61
pubmed: 19127595
J Parkinsons Dis. 2019;9(2):351-359
pubmed: 30909247
Parkinsonism Relat Disord. 2014 Jan;20(1):47-52
pubmed: 24126022
Lancet Neurol. 2017 Nov;16(11):908-916
pubmed: 28958801
Front Neurol. 2017 Oct 30;8:551
pubmed: 29163328
J Neural Transm (Vienna). 2018 Oct;125(10):1417-1432
pubmed: 30145631
Arch Neurol. 2009 Dec;66(12):1460-8
pubmed: 19822770
J Parkinsons Dis. 2020;10(3):1075-1085
pubmed: 32538866
AJR Am J Roentgenol. 1987 Aug;149(2):351-6
pubmed: 3496763
Parkinsonism Relat Disord. 2015 Oct;21(10):1148-55
pubmed: 26228080
Parkinsonism Relat Disord. 2019 Sep;66:105-109
pubmed: 31324555
Cell Mol Neurobiol. 2012 Jul;32(5):661-6
pubmed: 22297542
Neurol Sci. 2018 Nov;39(11):1971-1976
pubmed: 30109466
Int J Geriatr Psychiatry. 2012 Jul;27(7):755-62
pubmed: 21919059
Mov Disord. 2016 Oct;31(10):1518-1526
pubmed: 27324570
Med Sci Sports Exerc. 2003 Aug;35(8):1381-95
pubmed: 12900694
Can J Neurol Sci. 2016 Jan;43(1):113-9
pubmed: 26189779
Mov Disord Clin Pract. 2018 Jan-Feb;5(1):47-53
pubmed: 29662921
J Gerontol A Biol Sci Med Sci. 2019 May 16;74(6):949-956
pubmed: 31095709
Mov Disord. 2019 Jan;34(1):58-66
pubmed: 30653734
Mov Disord. 2021 Jan;36(1):106-117
pubmed: 33002231
East Mediterr Health J. 2012 Apr;18(4):304-10
pubmed: 22768690
Front Neurol. 2018 May 24;9:357
pubmed: 29881368
Mov Disord. 2008 Nov 15;23(15):2129-70
pubmed: 19025984
Mov Disord. 2015 Oct;30(12):1591-601
pubmed: 26474316
Neuroimage Clin. 2019;23:101870
pubmed: 31150958
Mov Disord. 2005 Feb;20(2):224-30
pubmed: 15384126
Can J Public Health. 1992 Jul-Aug;83 Suppl 2:S7-11
pubmed: 1468055
Front Aging Neurosci. 2017 Dec 04;9:394
pubmed: 29255414
Br J Clin Pharmacol. 2012 Aug;74(2):267-83
pubmed: 22283961
Arch Neurol. 2002 Nov;59(11):1724-8
pubmed: 12433259
J Geriatr Phys Ther. 2006;29(2):64-8
pubmed: 16914068
J Neurol Sci. 1993 Jan;114(1):7-12
pubmed: 8433101
Eur J Neurol. 2015 Mar;22(3):457-63
pubmed: 24888502
Neurobiol Aging. 2020 Dec;96:267-276
pubmed: 33130544
J Neurol. 2012 Dec;259(12):2621-31
pubmed: 22711157
Neurodegener Dis. 2019;19(2):51-59
pubmed: 31487721
Mov Disord. 2007 Oct 15;22(13):1901-11
pubmed: 17674410
Mov Disord. 2006 Feb;21(2):223-9
pubmed: 16161159
Mov Disord. 2019 Jan;34(1):67-77
pubmed: 30468694
Parkinsonism Relat Disord. 2019 Dec;69:48-54
pubmed: 31677455
Parkinsonism Relat Disord. 2021 Apr;85:5-10
pubmed: 33636481
Neurol Clin. 2016 Nov;34(4):955-965
pubmed: 27720003
Neurosci Biobehav Rev. 2020 Jan;108:48-77
pubmed: 31666179
Mov Disord. 2018 May;33(5):771-782
pubmed: 29572948
J Parkinsons Dis. 2019;9(4):665-679
pubmed: 31450510