Insight Into the Anti-staphylococcal Activity of JBC 1847 at Sub-Inhibitory Concentration.

Gram-positive bacteria RNA transcriptomics antimicrobial resistance mode of action phenothiazine derivative

Journal

Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977

Informations de publication

Date de publication:
2021
Historique:
received: 29 09 2021
accepted: 25 11 2021
entrez: 24 1 2022
pubmed: 25 1 2022
medline: 25 1 2022
Statut: epublish

Résumé

Multidrug-resistant pathogens constitute a serious global issue and, therefore, novel antimicrobials with new modes of action are urgently needed. Here, we investigated the effect of a phenothiazine derivative (JBC 1847) with high antimicrobial activity on

Identifiants

pubmed: 35069485
doi: 10.3389/fmicb.2021.786173
pmc: PMC8766816
doi:

Types de publication

Journal Article

Langues

eng

Pagination

786173

Informations de copyright

Copyright © 2022 Ronco, Kappel, Aragao, Biagi, Svenningsen, Christensen, Permin, Saaby, Holmstrøm, Klitgaard, Sabat, Akkerboom, Monaco, Tinelli, Friedrich, Jana and Olsen.

Déclaration de conflit d'intérêts

AP was employed by company Unibrains. LS and KH were employed by company Bioneer A/S. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Troels Ronco (T)

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Line H Kappel (LH)

Research Unit of Molecular Microbiology, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

Maria F Aragao (MF)

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Niccolo Biagi (N)

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Søren Svenningsen (S)

Department of Chemistry, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.

Jørn B Christensen (JB)

Department of Chemistry, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.

Anders Permin (A)

Unibrains, Virum, Denmark.

Lasse Saaby (L)

Bioneer A/S, Hørsholm, Denmark.

Kim Holmstrøm (K)

Bioneer A/S, Hørsholm, Denmark.

Janne K Klitgaard (JK)

Research Unit of Molecular Microbiology, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Research Unit of Clinical Microbiology, Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.

Artur J Sabat (AJ)

Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Viktoria Akkerboom (V)

Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Monica Monaco (M)

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

Marco Tinelli (M)

Division of Infectious and Tropical Diseases, Hospital of Lodi, Lodi, Italy.

Alexander W Friedrich (AW)

Department of Medical Microbiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Bimal Jana (B)

Department of Biology, Boston College, Chestnut Hill, MA, United States.

Rikke H Olsen (RH)

Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Classifications MeSH