Mitochondrial DNA Footprints from Western Eurasia in Modern Mongolia.
Eurasian Steppe
Inner Asia
Mongolia genetic history
mitochondrial DNA phylogeny
modern mitogenomes
mtDNA haplogroups
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
11
2021
accepted:
14
12
2021
entrez:
24
1
2022
pubmed:
25
1
2022
medline:
25
1
2022
Statut:
epublish
Résumé
Mongolia is located in a strategic position at the eastern edge of the Eurasian Steppe. Nomadic populations moved across this wide area for millennia before developing more sedentary communities, extended empires, and complex trading networks, which connected western Eurasia and eastern Asia until the late Medieval period. We provided a fine-grained portrait of the mitochondrial DNA (mtDNA) variation observed in present-day Mongolians and capable of revealing gene flows and other demographic processes that took place in Inner Asia, as well as in western Eurasia. The analyses of a novel dataset (N = 2,420) of mtDNAs highlighted a clear matrilineal differentiation within the country due to a mixture of haplotypes with eastern Asian (EAs) and western Eurasian (WEu) origins, which were differentially lost and preserved. In a wider genetic context, the prevalent EAs contribution, larger in eastern and central Mongolian regions, revealed continuous connections with neighboring Asian populations until recent times, as attested by the geographically restricted haplotype-sharing likely facilitated by the Genghis Khan's so-called
Identifiants
pubmed: 35069708
doi: 10.3389/fgene.2021.819337
pii: 819337
pmc: PMC8773455
doi:
Types de publication
Journal Article
Langues
eng
Pagination
819337Informations de copyright
Copyright © 2022 Cardinali, Bodner, Capodiferro, Amory, Rambaldi Migliore, Gomez, Myagmar, Dashzeveg, Carano, Woodward, Parson, Perego, Lancioni and Achilli.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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