Polycystic ovary syndrome and type 2 diabetes mellitus: A state-of-the-art review.
Diabetes
Dysglycemia
Insulin resistance
Polycystic ovary syndrome
Women
Journal
World journal of diabetes
ISSN: 1948-9358
Titre abrégé: World J Diabetes
Pays: United States
ID NLM: 101547524
Informations de publication
Date de publication:
15 Jan 2022
15 Jan 2022
Historique:
received:
20
04
2021
revised:
30
06
2021
accepted:
25
12
2021
entrez:
24
1
2022
pubmed:
25
1
2022
medline:
25
1
2022
Statut:
ppublish
Résumé
Polycystic ovary syndrome (PCOS) often coexists with a wide spectrum of dysglycemic conditions, ranging from impaired glucose tolerance to type 2 diabetes mellitus (T2D), which occur to a greater extent compared to healthy body mass index-matched women. This concurrence of disorders is mainly attributed to common pathogenetic pathways linking the two entities, such as insulin resistance. However, due to methodological flaws in the available studies and the multifaceted nature of the syndrome, there has been substantial controversy as to the exact association between T2D and PCOS which has not yet been elucidated. The aim of this review is to present the best available evidence regarding the epidemiology of dysglycemia in PCOS, the unique pathophysiological mechanisms underlying the progression of dysglycemia, the most appropriate methods for assessing glycemic status and the risk factors for T2D development in this population, as well as T2D risk after transition to menopause. Proposals for application of a holistic approach to enable optimal management of T2D risk in PCOS are also provided. Specifically, adoption of a healthy lifestyle with adherence to improved dietary patterns, such the Mediterranean diet, avoidance of consumption of endocrine-disrupting foods and beverages, regular exercise, and the effect of certain medications, such as metformin and glucagon-like peptide 1 receptor agonists, are discussed. Furthermore, the maintenance of a healthy weight is highlighted as a key factor in achievement of a significant reduction of T2D risk in women with PCOS.
Identifiants
pubmed: 35070056
doi: 10.4239/wjd.v13.i1.5
pmc: PMC8771268
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
5-26Informations de copyright
©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors have no conflict of interest to disclose.
Références
Hum Reprod. 2001 Sep;16(9):1995-8
pubmed: 11527911
Hum Reprod. 2013 Apr;28(4):1062-8
pubmed: 23335611
Adv Nutr. 2021 Feb 1;12(1):161-178
pubmed: 32805007
J Clin Invest. 1995 Jul;96(1):520-7
pubmed: 7615824
Hum Reprod. 2008 Jun;23(6):1431-8
pubmed: 18359783
Hum Reprod. 2013 Aug;28(8):2228-34
pubmed: 23739218
J Clin Endocrinol Metab. 2008 Jul;93(7):2670-8
pubmed: 18460557
PLoS One. 2017 Feb 13;12(2):e0171315
pubmed: 28192447
PLoS One. 2016 Nov 30;11(11):e0167036
pubmed: 27902723
J Clin Endocrinol Metab. 2020 Oct 1;105(10):
pubmed: 32621748
Reprod Biol Endocrinol. 2018 Mar 27;16(1):27
pubmed: 29580250
Rev Endocr Metab Disord. 2015 Dec;16(4):289-97
pubmed: 26880303
Biomed Res Int. 2018 Mar 8;2018:6869705
pubmed: 29707577
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S429-S432
pubmed: 28416368
J Clin Endocrinol Metab. 2013 Dec;98(12):4655-63
pubmed: 24092832
Diabetes Care. 2006 May;29(5):1130-9
pubmed: 16644654
Gynecol Endocrinol. 2008 Jul;24(7):385-91
pubmed: 18645711
Hum Reprod. 2001 Mar;16(3):556-60
pubmed: 11228228
Hum Reprod. 2017 Nov 1;32(11):2279-2286
pubmed: 29040530
Metabolism. 2018 Sep;86:33-43
pubmed: 29024702
Fertil Steril. 2012 Nov;98(5):1318-25.e1
pubmed: 22835450
Expert Rev Endocrinol Metab. 2016 Nov;11(6):449-454
pubmed: 30058915
Minerva Med. 2021 Feb 08;:
pubmed: 33555153
Clin Endocrinol (Oxf). 1996 Jan;44(1):85-90
pubmed: 8706299
Fertil Steril. 2009 May;91(5):1848-52
pubmed: 18439591
Eur J Public Health. 2016 Aug;26(4):699-706
pubmed: 27423001
Clin Invest Med. 2016 Sep 11;39(4):E120-31
pubmed: 27619399
Endocrine. 2018 Jan;59(1):30-38
pubmed: 29052180
Curr Diab Rep. 2006 Feb;6(1):77-83
pubmed: 16522285
Fertil Steril. 2014 Apr;101(4):1123-8.e1
pubmed: 24502891
Diabetes. 2017 Mar;66(3):577-586
pubmed: 28223343
J Clin Endocrinol Metab. 2006 Jan;91(1):36-42
pubmed: 16219719
Nutrients. 2018 Nov 02;10(11):
pubmed: 30400199
BMC Hematol. 2019 Jan 9;19:2
pubmed: 30647919
J Clin Endocrinol Metab. 1999 Jan;84(1):165-9
pubmed: 9920077
Diabetes. 2004 Sep;53(9):2353-8
pubmed: 15331545
Hum Reprod Update. 2018 Jul 1;24(4):455-467
pubmed: 29590375
Fertil Steril. 2010 Jul;94(2):673-7
pubmed: 19394003
Hum Reprod. 2017 Feb;32(2):423-431
pubmed: 28031324
Eur J Nutr. 2020 Oct;59(7):2841-2856
pubmed: 32372265
Eur J Endocrinol. 2014 Oct;171(4):P1-29
pubmed: 24849517
J Trace Elem Med Biol. 2017 Jul;42:92-96
pubmed: 28595797
Gynecol Endocrinol. 2016;32(2):143-6
pubmed: 26507209
Eur J Endocrinol. 2018 Sep;179(3):D1-D14
pubmed: 29921567
Eur J Endocrinol. 2019 Jan 1;180(1):41-50
pubmed: 30400047
Horm Metab Res. 2018 Mar;50(3):193-200
pubmed: 29523006
Fertil Steril. 2021 Jun;115(6):1569-1575
pubmed: 33509630
Hum Reprod Open. 2017 Aug 19;2017(2):hox010
pubmed: 30895228
Endocr Pract. 2015 Dec;21(12):1415-26
pubmed: 26642102
Fertil Steril. 2009 May;91(5):1864-8
pubmed: 18565519
Fertil Steril. 2004 Jan;81(1):19-25
pubmed: 14711538
J Clin Endocrinol Metab. 2011 Dec;96(12):3794-803
pubmed: 21956415
Horm Res. 2001;55(2):65-70
pubmed: 11509861
J Clin Endocrinol Metab. 2015 Feb;100(2):544-50
pubmed: 25387258
Fertil Steril. 2015 Mar;103(3):795-801.e2
pubmed: 25585504
Hum Reprod Open. 2020 Jan 15;2020(1):hoz042
pubmed: 31976382
Endocrine. 2009 Oct;36(2):326-32
pubmed: 19688613
Hum Reprod. 2017 May 1;32(5):1075-1091
pubmed: 28333286
J Clin Endocrinol Metab. 2017 Oct 1;102(10):3848-3857
pubmed: 28938447
Clin Endocrinol (Oxf). 2008 Oct;69(4):634-41
pubmed: 18363886
Clin Endocrinol (Oxf). 2017 Dec;87(6):767-774
pubmed: 28834553
Nat Rev Dis Primers. 2016 Aug 11;2:16057
pubmed: 27510637
Sleep Breath. 2020 Mar;24(1):339-350
pubmed: 31111411
J Clin Endocrinol Metab. 2010 May;95(5):2038-49
pubmed: 20375205
PLoS One. 2021 Jan 19;16(1):e0245023
pubmed: 33465123
JAMA. 2006 Mar 15;295(11):1288-99
pubmed: 16537739
Metabolism. 2019 Apr;93:86-92
pubmed: 30710572
BJOG. 2009 Dec;116(13):1722-8
pubmed: 19775306
Diabetes. 2021 Feb;70(2):627-637
pubmed: 33158931
Med J Aust. 2007 Sep 17;187(6):328-31
pubmed: 17874978
Diabetes Care. 2016 Mar;39(3):472-85
pubmed: 26908931
Surg Obes Relat Dis. 2019 Jun;15(6):942-950
pubmed: 31113751
J Biol Regul Homeost Agents. 2014 Apr-Jun;28(2):203-11
pubmed: 25001653
Int J Clin Pract. 2016 Jun;70(6):450-61
pubmed: 27228266
Clin Endocrinol (Oxf). 2019 Jun;90(6):805-813
pubmed: 30866088
Gynecol Endocrinol. 2014 Sep;30(9):664-6
pubmed: 24734869
J Clin Endocrinol Metab. 1987 Sep;65(3):499-507
pubmed: 3305551
Diabetes. 1995 Aug;44(8):968-83
pubmed: 7622004
Fertil Steril. 2016 Nov;106(6):1510-1520.e2
pubmed: 27530062
Reprod Sci. 2022 Jan;29(1):69-83
pubmed: 33409871
BMJ. 2007 Feb 10;334(7588):299
pubmed: 17237299
J Clin Endocrinol Metab. 2015 Mar;100(3):942-50
pubmed: 25514100
Diabetes Care. 1999 Jan;22(1):141-6
pubmed: 10333916
Curr Vasc Pharmacol. 2019;17(6):564-572
pubmed: 29984659
Clin Endocrinol (Oxf). 2011 Nov;75(5):698-703
pubmed: 21605157
Arch Gynecol Obstet. 2017 Oct;296(4):661-677
pubmed: 28770353
Endocr Rev. 2012 Dec;33(6):981-1030
pubmed: 23065822
J Clin Endocrinol Metab. 2013 Dec;98(12):4565-92
pubmed: 24151290
J Clin Endocrinol Metab. 2020 Aug 1;105(8):
pubmed: 32525987
J Clin Endocrinol Metab. 2004 Jun;89(6):2942-5
pubmed: 15181081
Metabolism. 2017 Aug;73:22-35
pubmed: 28732568
Int J Endocrinol. 2020 Sep 16;2020:5150684
pubmed: 33014044
N Engl J Med. 2001 May 3;344(18):1343-50
pubmed: 11333990
Hum Reprod. 2016 Nov;31(11):2619-2631
pubmed: 27907900
Gynecol Endocrinol. 2009 Mar;25(3):199-204
pubmed: 19347711
Eur J Endocrinol. 2014 Sep;171(3):301-9
pubmed: 25053727
Nutrients. 2015 Jun 08;7(6):4555-77
pubmed: 26061015
Diabetologia. 2019 Oct;62(10):1761-1772
pubmed: 31451872
Curr Vasc Pharmacol. 2019;17(6):543-545
pubmed: 30816074
Gynecol Endocrinol. 2018 Mar;34(3):238-242
pubmed: 29068242
Fertil Steril. 2011 Nov;96(5):1275-80
pubmed: 21982282
J Clin Endocrinol Metab. 1993 May;76(5):1295-300
pubmed: 8388405
Eur J Endocrinol. 2015 Jan;172(1):79-88
pubmed: 25342852
Fertil Steril. 2011 Jan;95(1):210-5
pubmed: 20655529
J Womens Health (Larchmt). 2011 Jan;20(1):37-43
pubmed: 21194310
Hormones (Athens). 2014 Jan-Mar;13(1):65-73
pubmed: 24722128
Hum Reprod Update. 2020 Nov 1;26(6):942-960
pubmed: 32995872
Gynecol Endocrinol. 2018 May;34(5):370-377
pubmed: 29191127
Fertil Steril. 2016 Jan;105(1):194-201.e1-3
pubmed: 26407537
J Dermatol. 2013 Mar;40(3):188-92
pubmed: 23289590
Hum Reprod. 2015 Feb;30(2):466-72
pubmed: 25432918
Int J Endocrinol. 2020 Jun 8;2020:6276187
pubmed: 32587614
J Clin Endocrinol Metab. 1996 Mar;81(3):942-7
pubmed: 8772555
J Clin Endocrinol Metab. 2019 May 1;104(5):1841-1854
pubmed: 30544235
Curr Vasc Pharmacol. 2019;17(6):579-590
pubmed: 30156159
PLoS Med. 2020 Jun 23;17(6):e1003132
pubmed: 32574161
Int J Endocrinol. 2019 Nov 26;2019:4386401
pubmed: 31885557
Hum Reprod Update. 2015 Sep-Oct;21(5):560-74
pubmed: 26060208
Endocr Connect. 2017 Nov;6(8):601-606
pubmed: 28912337
J Clin Endocrinol Metab. 2011 Mar;96(3):E480-4
pubmed: 21193545
Clin Endocrinol (Oxf). 2019 Sep;91(3):411-416
pubmed: 31152677
Acta Diabetol Lat. 1983 Apr-Jun;20(2):135-42
pubmed: 6224386
Fertil Steril. 2014 Jul;102(1):250-256.e3
pubmed: 24825420
Eur J Endocrinol. 2014 Apr 10;170(5):727-39
pubmed: 24591551
Clin Chem Lab Med. 2007;45(5):639-44
pubmed: 17484627
Int J Gynaecol Obstet. 2010 Feb;108(2):148-51
pubmed: 19932893
Horm Metab Res. 2020 Mar;52(3):179-185
pubmed: 32074632
Circulation. 2019 Sep 10;140(11):e596-e646
pubmed: 30879355
Obstet Gynecol. 2012 Feb;119(2 Pt 1):263-9
pubmed: 22270277
Trends Endocrinol Metab. 2019 Mar;30(3):150-162
pubmed: 30712978
J Clin Endocrinol Metab. 1983 Aug;57(2):356-9
pubmed: 6223044
Clin Endocrinol (Oxf). 2021 Oct;95(4):531-541
pubmed: 33460482
Int J Gynaecol Obstet. 2009 Apr;105(1):29-31
pubmed: 19155002
J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1420-e1432
pubmed: 32995892
CMAJ. 2007 Mar 27;176(7):933-8
pubmed: 17389441
Diabetes. 2012 Sep;61(9):2369-74
pubmed: 22698921
Hum Reprod. 2018 Sep 1;33(9):1602-1618
pubmed: 30052961
Hum Reprod. 2006 Aug;21(8):2027-32
pubmed: 16684838
Diabetol Metab Syndr. 2019 Jul 23;11:58
pubmed: 31367235
Diabetologia. 2006 Nov;49(11):2572-9
pubmed: 16972044
Reprod Biomed Online. 2019 Aug;39(2):332-342
pubmed: 31229399
Maturitas. 2018 Nov;117:6-10
pubmed: 30314563
J Clin Endocrinol Metab. 1980 Jan;50(1):113-6
pubmed: 7350174
Diabet Med. 2008 Mar;25(3):296-302
pubmed: 18307457
Hormones (Athens). 2020 Dec;19(4):531-539
pubmed: 32451980
Curr Diabetes Rev. 2011 Mar;7(2):135-42
pubmed: 21348815
Diabetes Care. 2002 Jan;25(1):55-60
pubmed: 11772901
J Clin Endocrinol Metab. 2005 Jun;90(6):3236-42
pubmed: 15797965
Diabetes Care. 2013 Feb;36(2):480-9
pubmed: 23349152
Clin Endocrinol (Oxf). 2000 May;52(5):595-600
pubmed: 10792339