Olfactory and Gustatory Dysfunction in 2019 Novel Coronavirus: An Updated Systematic Review and Meta-analysis.

Ageusia COVID-19 and smell impairment anosmia sensation disorder taste

Journal

International journal of preventive medicine
ISSN: 2008-7802
Titre abrégé: Int J Prev Med
Pays: Iran
ID NLM: 101535380

Informations de publication

Date de publication:
2021
Historique:
received: 17 08 2020
accepted: 21 01 2021
entrez: 24 1 2022
pubmed: 25 1 2022
medline: 25 1 2022
Statut: epublish

Résumé

Evidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients. In this systematic review, a comprehensive search was carried out systematically through e-databases including PubMed, EMBASE, Scopus, and Web of Science (WoS); that was limited to English-language studies published from 2019 up to 6 Among 28 eligible included studies in this systematic review, finally, 22 studies met the eligibility criteria and were included in the meta-analysis. According to the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of any olfactory dysfunction, anosmia, and hyposmia was 55% (40%-70%), 40% (22%-57%), and 40% (20%-61%) respectively. The pooled estimated prevalence of any gustatory dysfunction, ageusia, and dysgeusia was 41% (23%-59%), 31% (3%-59%), and 34% (19%-48%) respectively. Olfactory and gustatory dysfunction is prevalent among COVID-19 patients. Therefore, olfactory and gustatory dysfunction seems to be part of important symptoms and notify for the diagnosis of COVID-19, especially in the early phase of the infection.

Sections du résumé

BACKGROUND BACKGROUND
Evidence showed that partial or complete loss of smell and taste might be a possible primary symptom of the 2019 novel coronavirus (COVID-19). This study aimed to systematically review and pool all available evidence on the olfactory and gustatory dysfunction in COVID-19 patients.
METHODS METHODS
In this systematic review, a comprehensive search was carried out systematically through e-databases including PubMed, EMBASE, Scopus, and Web of Science (WoS); that was limited to English-language studies published from 2019 up to 6
RESULTS RESULTS
Among 28 eligible included studies in this systematic review, finally, 22 studies met the eligibility criteria and were included in the meta-analysis. According to the random effect meta-analysis, the global pooled prevalence (95% confidence interval) of any olfactory dysfunction, anosmia, and hyposmia was 55% (40%-70%), 40% (22%-57%), and 40% (20%-61%) respectively. The pooled estimated prevalence of any gustatory dysfunction, ageusia, and dysgeusia was 41% (23%-59%), 31% (3%-59%), and 34% (19%-48%) respectively.
CONCLUSIONS CONCLUSIONS
Olfactory and gustatory dysfunction is prevalent among COVID-19 patients. Therefore, olfactory and gustatory dysfunction seems to be part of important symptoms and notify for the diagnosis of COVID-19, especially in the early phase of the infection.

Identifiants

DOI: 10.4103/ijpvm.IJPVM_484_20 PMID: 35070203 PMC: PMC8724794
pubmed: 35070203
doi: 10.4103/ijpvm.IJPVM_484_20
pii: IJPVM-12-170
pmc: PMC8724794
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

170

Informations de copyright

Copyright: © 2021 International Journal of Preventive Medicine.

Déclaration de conflit d'intérêts

There are no conflicts of interest.

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Auteurs

Marzieh Esmaeili (M)

Department of Health Information Management, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran.

Fatemeh Abdi (F)

Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Gita Shafiee (G)

Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Hamid Asayesh (H)

Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran.

Zahra Esmaeili Abdar (ZE)

Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Fereshteh Baygi (F)

Center of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark.

Mostafa Qorbani (M)

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Classifications MeSH