Current Prophylaxis and Treatment Approaches for Acute Graft-Versus-Host Disease in Haematopoietic Stem Cell Transplantation for Children With Acute Lymphoblastic Leukaemia.
acute graft-versus-host disease (aGVHD)
acute lymphoblastic leukaemia
children
hematopoietic (stem) cell transplantation
management
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
09
2021
accepted:
09
12
2021
entrez:
24
1
2022
pubmed:
25
1
2022
medline:
25
1
2022
Statut:
epublish
Résumé
Acute graft-versus-host disease (aGvHD) continues to be a leading cause of morbidity and mortality following allogeneic haematopoietic stem cell transplantation (HSCT). However, higher event-free survival (EFS) was observed in patients with acute lymphoblastic leukaemia (ALL) and grade II aGvHD vs. patients with no or grade I GvHD in the randomised, controlled, open-label, international, multicentre Phase III For Omitting Radiation Under Majority age (FORUM) trial. This finding suggests that moderate-severity aGvHD is associated with a graft-versus-leukaemia effect which protects against leukaemia recurrence. In order to optimise the benefits of HSCT for leukaemia patients, reduction of non-relapse mortality-which is predominantly caused by severe GvHD-is of utmost importance. Herein, we review contemporary prophylaxis and treatment options for aGvHD in children with ALL and the key challenges of aGvHD management, focusing on maintaining the graft-versus-leukaemia effect without increasing the severity of GvHD.
Identifiants
pubmed: 35071133
doi: 10.3389/fped.2021.784377
pmc: PMC8771910
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
784377Informations de copyright
Copyright © 2022 Wölfl, Qayed, Benitez Carabante, Sykora, Bonig, Lawitschka and Diaz-de-Heredia.
Déclaration de conflit d'intérêts
CD-d-H has acted as a consultant and speaker for and has received travel expenses from Novartis. MW has acted as a consultant for and has received travel expenses from Novartis. MW also received travel expenses from Mallinckrodt Pharmaceuticals. MQ received honoraria from Mesoblasts, Medexus, Jazz Pharmaceuticals, and Novartis. HB owns IP and receives royalties and licencing fees from Medac for an MSC product for aGvHD which he co-invented. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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