Serum levels of vitamin D and immune system function in patients with COVID-19 admitted to intensive care unit.
ACE2, Angiotensin-converting enzyme 2
ARDS, Acute respiratory distress syndrome
COVID-19
Cytokines
ELISA, Enzyme linked immunosorbent assay
IFN-γ, Interferon gamma
Immune Response
Lymphocytes
PBMCs, Peripheral blood mononuclear cells
SARS Coronavirus
TNF-α, Tumor necrosis factor-alpha
Vitamin D
Journal
Gene reports
ISSN: 2452-0144
Titre abrégé: Gene Rep
Pays: United States
ID NLM: 101680713
Informations de publication
Date de publication:
Mar 2022
Mar 2022
Historique:
received:
11
10
2021
revised:
18
12
2021
accepted:
11
01
2022
entrez:
24
1
2022
pubmed:
25
1
2022
medline:
25
1
2022
Statut:
ppublish
Résumé
Vitamin D is believed to affect the functionality of the immune system for the prevention of coronavirus disease. To investigate the role of this vitamin against the Coronavirus, this study analyzed the serum levels of vitamin D, the transcription pattern of inflammatory cytokines, and the frequency of total lymphocytes, TCD4 This study diagnosed and evaluated 100 patients. Frequency of lymphocytes was determined using flow cytometry. Cytokine expression levels were measured using Real-Time PCR. Serum levels of vitamin D and cytokines levels in cultured cell supernatant were measured by ELISA. Patients with COVID-19 exhibited decreased serum levels of vitamin D versus the healthy participants ( These findings suggest a probable association among vitamin D concentrations, immune system function, and risk of COVID-19 infection. As a result, it is recommended that vitamin D be considered as a candidate for handling and controlling COVID-19 because of its ability to target the cytokine storm and its antiviral effects.
Identifiants
pubmed: 35071823
doi: 10.1016/j.genrep.2022.101509
pii: S2452-0144(22)00017-6
pmc: PMC8761022
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101509Informations de copyright
© 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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