Ultra-high-throughput Ca

Cell biology Functional aspects of cell biology Methodology in biological sciences

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
21 Jan 2022
Historique:
received: 27 07 2021
revised: 12 11 2021
accepted: 29 12 2021
entrez: 24 1 2022
pubmed: 25 1 2022
medline: 25 1 2022
Statut: epublish

Résumé

Antiplatelet drugs targeting G-protein-coupled receptors (GPCRs), used for the secondary prevention of arterial thrombosis, coincide with an increased bleeding risk. Targeting ITAM-linked receptors, such as the collagen receptor glycoprotein VI (GPVI), is expected to provide a better antithrombotic-hemostatic profile. Here, we developed and characterized an ultra-high-throughput (UHT) method based on intracellular [Ca

Identifiants

pubmed: 35072010
doi: 10.1016/j.isci.2021.103718
pii: S2589-0042(21)01688-6
pmc: PMC8762394
doi:

Types de publication

Journal Article

Langues

eng

Pagination

103718

Subventions

Organisme : British Heart Foundation
ID : RG/15/2/31224
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/20/7/34866
Pays : United Kingdom

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

J.W.M.H. is a cofounder and shareholder of FlowChamber B.V. The other authors declare no relevant conflicts of interest.

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Auteurs

Delia I Fernández (DI)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Platelet Proteomics Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

Isabella Provenzale (I)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Institute for Cardiovascular and Metabolic Research, University of Reading, RG6 6AX Reading, UK.

Hilaire Y F Cheung (HYF)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
ISASLeibniz-Institut fur Analytische Wissenschaften-ISAS-e.V., 44227 Dortmund, Germany.
Institute of Cardiovascular Sciences, Institute of Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.

Jan van Groningen (J)

Pivot Park Screening Centre, 5349 AB Oss, the Netherlands.

Bibian M E Tullemans (BME)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.

Alicia Veninga (A)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.

Joanne L Dunster (JL)

Institute for Cardiovascular and Metabolic Research, University of Reading, RG6 6AX Reading, UK.

Saman Honarnejad (S)

Pivot Park Screening Centre, 5349 AB Oss, the Netherlands.

Helma van den Hurk (H)

Pivot Park Screening Centre, 5349 AB Oss, the Netherlands.

Marijke J E Kuijpers (MJE)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Thrombosis Expertise Centre, Heart and Vascular Centre, Maastricht University Medical Centre, Maastricht, the Netherlands.

Johan W M Heemskerk (JWM)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, 6229 ER Maastricht, The Netherlands.
Synapse Research Institute, Kon. Emmaplein 7, 6214 AC, Maastricht, the Netherlands.

Classifications MeSH