Monitoring EPR Effect Dynamics during Nanotaxane Treatment with Theranostic Polymeric Micelles.
EPR effect
cancer nanomedicine
polymeric micelles
theranostics
tumor targeting
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
ISSN: 2198-3844
Titre abrégé: Adv Sci (Weinh)
Pays: Germany
ID NLM: 101664569
Informations de publication
Date de publication:
04 2022
04 2022
Historique:
revised:
09
01
2022
received:
26
08
2021
pubmed:
25
1
2022
medline:
8
4
2022
entrez:
24
1
2022
Statut:
ppublish
Résumé
Cancer nanomedicines rely on the enhanced permeability and retention (EPR) effect for efficient target site accumulation. The EPR effect, however, is highly heterogeneous among different tumor types and cancer patients and its extent is expected to dynamically change during the course of nanochemotherapy. Here the authors set out to longitudinally study the dynamics of the EPR effect upon single- and double-dose nanotherapy with fluorophore-labeled and paclitaxel-loaded polymeric micelles. Using computed tomography-fluorescence molecular tomography imaging, it is shown that the extent of nanomedicine tumor accumulation is predictive for therapy outcome. It is also shown that the interindividual heterogeneity in EPR-based tumor accumulation significantly increases during treatment, especially for more efficient double-dose nanotaxane therapy. Furthermore, for double-dose micelle therapy, tumor accumulation significantly increased over time, from 7% injected dose per gram (ID g
Identifiants
pubmed: 35072358
doi: 10.1002/advs.202103745
pmc: PMC8981450
doi:
Substances chimiques
Micelles
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2103745Subventions
Organisme : German Research Foundation
ID : GRK 2375
Organisme : German Research Foundation
ID : 331065168
Organisme : German Research Foundation
ID : SFB 1382
Organisme : German Research Foundation
ID : 403224013
Organisme : German Research Foundation
ID : SFB 1066
Organisme : German Research Foundation
ID : LA2937/4-1
Organisme : German Research Foundation
ID : SH1223/1-1
Organisme : German Federal Ministry of Research and Education
ID : PP-TNBC
Organisme : German Federal Ministry of Research and Education
ID : 16GW0319K
Organisme : European Union
ID : EFRE-0801767
Organisme : European Research Council
ID : 864121
Pays : International
Informations de copyright
© 2022 The Authors. Advanced Science published by Wiley-VCH GmbH.
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