A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk.
ageing
ageing clocks
biological age
biomarkers
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
24 01 2022
24 01 2022
Historique:
received:
19
03
2021
accepted:
20
12
2021
pubmed:
25
1
2022
medline:
14
4
2022
entrez:
24
1
2022
Statut:
ppublish
Résumé
Biological age (BA), a measure of functional capacity and prognostic of health outcomes that discriminates between individuals of the same chronological age (chronAge), has been estimated using a variety of biomarkers. Previous comparative studies have mainly used epigenetic models (clocks), we use ~1000 participants to compare fifteen omics ageing clocks, with correlations of 0.21-0.97 with chronAge, even with substantial sub-setting of biomarkers. These clocks track common aspects of ageing with 95% of the variance in chronAge being shared among clocks. The difference between BA and chronAge - omics clock age acceleration (OCAA) - often associates with health measures. One year's OCAA typically has the same effect on risk factors/10-year disease incidence as 0.09/0.25 years of chronAge. Epigenetic and IgG glycomics clocks appeared to track generalised ageing while others capture specific risks. We conclude BA is measurable and prognostic and that future work should prioritise health outcomes over chronAge.
Identifiants
pubmed: 35073279
pii: 203847
doi: 10.18632/aging.203847
pmc: PMC8833109
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
623-659Subventions
Organisme : Chief Scientist Office
ID : CZB/4/710
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 104036/Z/14/Z
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : CZD/16/6
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R026408/1
Pays : United Kingdom
Organisme : Arthritis Research UK
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : CZB/4/276
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_U127592696
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216767/Z/19/Z
Pays : United Kingdom
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