Human studies of mitochondrial biology demonstrate an overall lack of binary sex differences: A multivariate meta-analysis.
mitochondrion
mtDNAcn
respirometry
sex differences
sexual dimorphism
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
02 2022
02 2022
Historique:
revised:
18
12
2021
received:
02
11
2021
accepted:
21
12
2021
entrez:
24
1
2022
pubmed:
25
1
2022
medline:
15
2
2022
Statut:
ppublish
Résumé
Mitochondria are maternally inherited organelles that play critical tissue-specific roles, including hormone synthesis and energy production, that influence human development, health, and aging. However, whether mitochondria from women and men exhibit consistent biological differences remains unclear, representing a major gap in knowledge. This meta-analysis systematically examined four domains and six subdomains of mitochondrial biology (total 39 measures), including mitochondrial content, respiratory capacity, reactive oxygen species (ROS) production, morphometry, and mitochondrial DNA copy number. Standardized effect sizes (Hedge's g) of sex differences were computed for each measure using data in 2258 participants (51.5% women) from 50 studies. Only two measures demonstrated aggregate binary sex differences: higher mitochondrial content in women's WAT and isolated leukocyte subpopulations (g = 0.20, χ
Identifiants
pubmed: 35073429
doi: 10.1096/fj.202101628R
pmc: PMC9885138
mid: NIHMS1864556
doi:
Substances chimiques
DNA, Mitochondrial
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22146Subventions
Organisme : NIA NIH HHS
ID : R01 AG054523
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066828
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG061805
Pays : United States
Organisme : NIMH NIH HHS
ID : R21 MH123927
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH119336
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH122706
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG057864
Pays : United States
Informations de copyright
© 2022 Federation of American Societies for Experimental Biology.
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