Correlates of psychotic like experiences (PLEs) during Pandemic: An online study investigating a possible link between the SARS-CoV-2 infection and PLEs among adolescents.
Adolescence
Pandemic
Psychiatry
Psychotic like experiences
SARS-CoV-2
Journal
Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
12
06
2021
revised:
27
09
2021
accepted:
28
12
2021
pubmed:
26
1
2022
medline:
1
4
2022
entrez:
25
1
2022
Statut:
ppublish
Résumé
This study investigated whether SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug usage contribute to psychotic-like experiences (PLEs) among adolescents during the pandemic. We also aimed to explore whether baseline inflammatory markers or the number of SARS-CoV-2-related symptoms are associated with PLEs, and the latter is mediated by internalizing symptoms. Altogether, 684 adolescents aged 12-18 (SARS-CoV-2 group n = 361, control group (CG) n = 323) were recruited. The Community Assessment of Psychic Experiences-42-Positive Dimension (CAPE-Pos), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Pittsburg Sleep Quality Index (PSQI) questionnaires were completed by all volunteers using an online survey. C-reactive Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were recorded in the SARS-CoV-2 group. Group comparisons, correlations, logistic regression, and bootstrapped mediation analyses were performed. CAPE-Pos-Frequency/Stress scores were significantly higher, whereas GAD-7-Total and PSQI-Total scores were significantly lower in SARS-CoV-2 than CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-symptoms were positively correlated with CAPE-Pos-Frequency/Stress scores. Besides SARS-CoV-2, cigarette use, GAD-7, and PHQ-9 scores significantly contributed to the presence of at least one CAPE-Pos "often" or "almost always". PHQ-9 and GAD-7 fully mediated the relationship between the number of SARS-CoV-2 symptoms and CAPE-Pos-Frequency. This study is the first to show a possible relationship between SARS-CoV-2 infection and PLEs among adolescents. Depression, anxiety, and cigarette use also contributed to PLEs. The number of SARS-Cov-2-symptoms and PLEs association was fully mediated by internalizing symptoms, but prospective studies will need to confirm this result.
Sections du résumé
BACKGROUND
This study investigated whether SARS-CoV-2 infection, depression, anxiety, sleep problems, cigarette, alcohol, drug usage contribute to psychotic-like experiences (PLEs) among adolescents during the pandemic. We also aimed to explore whether baseline inflammatory markers or the number of SARS-CoV-2-related symptoms are associated with PLEs, and the latter is mediated by internalizing symptoms.
METHODS
Altogether, 684 adolescents aged 12-18 (SARS-CoV-2 group n = 361, control group (CG) n = 323) were recruited. The Community Assessment of Psychic Experiences-42-Positive Dimension (CAPE-Pos), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Pittsburg Sleep Quality Index (PSQI) questionnaires were completed by all volunteers using an online survey. C-reactive Protein and hemogram values, and SARS-CoV-2-related symptoms during the acute infection period were recorded in the SARS-CoV-2 group. Group comparisons, correlations, logistic regression, and bootstrapped mediation analyses were performed.
RESULTS
CAPE-Pos-Frequency/Stress scores were significantly higher, whereas GAD-7-Total and PSQI-Total scores were significantly lower in SARS-CoV-2 than CG. Among the SARS-CoV-2 group, monocyte count and the number of SARS-CoV-2-symptoms were positively correlated with CAPE-Pos-Frequency/Stress scores. Besides SARS-CoV-2, cigarette use, GAD-7, and PHQ-9 scores significantly contributed to the presence of at least one CAPE-Pos "often" or "almost always". PHQ-9 and GAD-7 fully mediated the relationship between the number of SARS-CoV-2 symptoms and CAPE-Pos-Frequency.
CONCLUSIONS
This study is the first to show a possible relationship between SARS-CoV-2 infection and PLEs among adolescents. Depression, anxiety, and cigarette use also contributed to PLEs. The number of SARS-Cov-2-symptoms and PLEs association was fully mediated by internalizing symptoms, but prospective studies will need to confirm this result.
Identifiants
pubmed: 35074530
pii: S0920-9964(21)00533-8
doi: 10.1016/j.schres.2021.12.049
pmc: PMC8730741
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
36-43Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Références
Eur Arch Psychiatry Clin Neurosci. 2022 Feb;272(1):5-15
pubmed: 33811552
Psychol Med. 2011 Jan;41(1):47-58
pubmed: 20346196
Schizophr Bull. 2006 Apr;32(2):352-9
pubmed: 16254060
J Psychosom Res. 2021 Apr;143:110399
pubmed: 33618149
Aust N Z J Psychiatry. 2009 Feb;43(2):118-28
pubmed: 19153919
Psychosomatics. 2020 Sep - Oct;61(5):551-555
pubmed: 32593479
Psychol Med. 2009 Sep;39(9):1457-67
pubmed: 19215630
Sleep. 2021 Jul 9;44(7):
pubmed: 33567067
Asian J Psychiatr. 2017 Apr;26:58-65
pubmed: 28483093
Transl Psychiatry. 2021 Jan 7;11(1):21
pubmed: 33414383
Psychol Med. 2019 Jul;49(10):1589-1599
pubmed: 31088578
Br J Psychiatry. 2006 Jun;188:519-26
pubmed: 16738341
Psychiatry Res. 2020 Jul;289:113052
pubmed: 32388178
J Psychiatr Res. 2020 Nov;130:177-179
pubmed: 32823051
Early Interv Psychiatry. 2019 Dec;13(6):1465-1469
pubmed: 30712294
Front Med (Lausanne). 2020 Jun 09;7:301
pubmed: 32582743
Nat Sci Sleep. 2021 Feb 15;13:191-199
pubmed: 33623460
Global Health. 2020 Jul 6;16(1):57
pubmed: 32631403
Biol Psychiatry Glob Open Sci. 2021 Dec;1(4):310-316
pubmed: 34877564
Schizophr Res. 2019 Apr;206:149-156
pubmed: 30545759
J Acad Consult Liaison Psychiatry. 2021 Mar-Apr;62(2):211-219
pubmed: 33198962
Arch Gen Psychiatry. 2010 Apr;67(4):328-38
pubmed: 20368509
Eur Psychiatry. 2011 Sep;26(6):396-401
pubmed: 21334860
Schizophr Res. 2012 Sep;140(1-3):104-9
pubmed: 22789670
Psychol Med. 2012 Sep;42(9):1857-63
pubmed: 22225730
Sleep Med. 2012 Sep;13(8):1021-7
pubmed: 22841033
Schizophr Bull. 2019 Jun 18;45(4):742-751
pubmed: 30169868
Psychol Med. 2021 Jan 13;:1-9
pubmed: 33436120
JAMA Psychiatry. 2021 Jun 1;78(6):682-683
pubmed: 33769431
JAMA Psychiatry. 2014 Oct;71(10):1121-8
pubmed: 25133871
Schizophr Bull. 2013 Sep;39(5):1018-26
pubmed: 22927672
Psychiatry Res. 2020 Aug;290:113097
pubmed: 32480119
Br J Psychiatry. 2007 Apr;190:339-43
pubmed: 17401041
J Clin Psychiatry. 2018 Oct 2;79(6):
pubmed: 30289630
Psychol Med. 2011 Jan;41(1):1-6
pubmed: 20624328
Schizophr Res. 2020 Aug;222:520-521
pubmed: 32405153
Schizophr Res. 2020 Jan;215:424-429
pubmed: 31387824
Neurosci Lett. 2021 Jan 10;741:135491
pubmed: 33220366
Ann Hematol. 2021 Mar;100(3):675-689
pubmed: 33523290
JAMA Psychiatry. 2018 Mar 1;75(3):240-246
pubmed: 29344610
Schizophr Res. 2021 May;231:3-9
pubmed: 33725647
Br J Hosp Med (Lond). 2020 Aug 2;81(8):1-10
pubmed: 32845750
Schizophr Bull. 2016 Jan;42(1):34-44
pubmed: 26150674
Infect Drug Resist. 2020 Jul 22;13:2485-2493
pubmed: 32801787
Pediatrics. 2010 Dec;126(6):1117-23
pubmed: 21041282
Ann Clin Psychiatry. 2017 Nov;29(4):227-234A
pubmed: 29069107
Psychiatry Res. 2020 Aug;290:113115
pubmed: 32512352
Psychoneuroendocrinology. 2021 May;127:105200
pubmed: 33740587
Psychol Med. 2002 Feb;32(2):347-58
pubmed: 11866327
Psychol Med. 2014 Jul;44(10):2199-211
pubmed: 24342773
Brain Behav Immun. 2018 Jul;71:28-36
pubmed: 29730395
Psychol Med. 2009 Apr;39(4):625-34
pubmed: 18606046
J Abnorm Psychol. 2015 Aug;124(3):674-684
pubmed: 25938536
Schizophr Res. 2008 Feb;99(1-3):125-33
pubmed: 18248792
Schizophr Res. 2018 May;195:149-153
pubmed: 29055569